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Clonidine, Clopidogrel, Clorazepate

Sunday, August 2nd, 2009

Generic Name
Clonidine (KLAH-nih-dene)
Brand Names
Catapres-TTS-2
Catapres-TTS-1    Catapres-TTS-3
Type of Drug
Alpha receptor stimulant.
Prescribed For
High blood pressure, including hypertensive emergency (diastolic blood pressure over 120); also used for excess sweating, childhood growth delay, attention-deficit hyperactivity disorder (ADHD), Tourette’s syndrome, restless leg syndrome, schizophrenic psychosis, migraine, ulcerative colitis, painful or difficult menstruation, hot flashes related to menopause, diagnosis of pheochromocytoma (adrenal-gland tumor), kidney poisoning associated with cyclosporine, diabetic diarrhea, smoking cessation, methadone and opiate detoxification, withdrawal from alcohol and benzodiazepines such as Valium, nerve pain following herpes attack, and allergic reactions in the presence of asthma triggered by external sources.
General Information
Clonidine stimulates nerve endings in the brain called alphaadrenergic receptors. It reduces blood pressure by dilating (widening) blood vessels. Clonidine works quickly, decreasing blood pressure within 1 hour. The other uses of clonidine relate to its stimulation of alpha receptors in the body.
Cautions and Warnings
Do not take clonidine if you are allergic or sensitive to any of its ingredients.
People who have had a stroke or recent heart attack or who have cardiac insufficiency or chronic kidney failure should avoid taking clonidine.
Some people develop a tolerance of their clonidine dosage. If this happens, your blood pressure may increase and your doctor may prescribe a higher dose.
Never stop taking clonidine without your doctor’s knowledge. If you abruptly stop taking clonidine, you may experience an unusual increase in blood pressure accompanied by agitation, headache, nervousness, and severe reactions, possibly death. Restarting clonidine therapy or taking another antihypertensive can reverse these effects.
Clonidine may cause degeneration of the    See your eye doctor for regular GheCk Ups lfiyou are taking this drug.
); you require surgery, your doctor will continue your clonidine therapy until about 4 hours before surgery and resume it as soon as possible afterward.
People who develop skin sensitivity (symptoms include rash, itching, and swelling) to Catapres-TTS, the transdermal patch form of clonidine, may experience the same reactions with oral clonidine.
Possible Side Effects
Tablets
♦    Most common: dry mouth, drowsiness, dizziness, constipation, and sedation.
♦    Common: headache and fatigue. These effects tend to diminish within 4-6 weeks.
•    Less common: appetite loss, swelling or pain in the glands of the throat, nausea, vomiting, weight gain, blood-sugar elevation, breast pain or enlargement, worsening of congestive heart failure, heart palpitations, rapid heartbeat, painful blood-vessel spasm, abnormal heart rhythms, electrocardiogram changes, feeling unwell, changes in dream patterns, nightmares, difficulty sleeping, hallucinations, delirium, anxiety, depression, nervousness, restlessness, rash, hives, thinning or loss of scalp hair, difficult or painful urination, nighttime urination, retaining urine, decrease or loss of sex drive, weakness, muscle or joint pain, leg cramps, increased alcohol sensitivity, dryness and burning of the eyes, dry nose, loss of color, and fever.
Transdermal Patch
✓    Most common: dry mouth and drowsiness.
✓    Less common: constipation, nausea, changes in sense of taste, dry throat, fatigue, headache, lethargy, changes in sleep patterns, nervousness, dizziness, impotence, sexual difficulties, and mild skin reactions including itching, swelling, contact dermatitis, discoloration, burning, peeling, throbbing, white patches, and generalized rash. Rashes of the face and tongue have also occurred but cannot be specifically tied to transdermal clonidine.
Drug Interactions
•    Combining clonidine and a beta-adrenergic blocker may increase the severity of a drug-withdrawal reaction and rebound high MW pressure. This reaction may be very serious.
•    Combining verapamil and clonidine may lead to very low blood pressure and atrioventricular (AV) block (abnormality in heartbeat patterns). This reaction may be very serious.
O    Avoid alcohol, barbiturates, and sedatives because they increase the depressive effects of clonidine.
•    Tricyclic and other antidepressants, appetite suppressants, estrogens, stimulants, indomethacin and other nonsteroidal anti-inflammatory drugs (NSAIDs), and prazosin may counteract the effects of clonidine.
•    clonidine may reduce the therapeutic effects of levadopa +
carbidopa.
Food Interactions
The tablets are best taken on an empty stomach but may be taken with food if they upset your stomach.
Usual Dose
Tablets
Adult: high blood pressure-100 mcg twice a day to start; may be raised by 100 mcg a day until maximum control is achieved. Take no more than 2400 mcg a day. Other uses-100-goo mcg a day, or up to 0.8 mcg per lb. of body weight in divided doses. Seniors should start with a lower dose and increase more slowly.
Child: 50-400 mcg orally twice a day.
Transdermal Patch
Adult: 100 mcg delivered daily from a patch applied once every 7 days. Up to two 300-mcg patches may be needed to control blood pressure. Transdermal dosage exceeding 600 mcg a day has not been shown to increase effectiveness.
Child: not recommended.
Overdosage
Symptoms of overdose are slow heartbeat, central- nervous-system depression, very slow breathing, low body temperature, pinpoint pupils, seizures, lethargy, agitation, irritability, nausea, vomiting, abnormal heart rhythms, mild increases in blood pressure followed by a rapid drop in blood pressure, dizziness, weakness, loss of reflexes, and vomiting. Victims should be taken to a hospital emergency room immediately. ALWAYS bring the prescription bottle or container.
Special Information
Gk’3t1161)e causes drowsiness in about 1/3 of people who take it. Be extremely careful while driving or performing any task that requires concentration. This effect is prominent during the first few weeks of clonidine therapy and then tends to decrease.
Do not take over-the-counter cough and cold medications unless directed by your doctor.
Call your doctor it you become depressed or have vivid dreams or nightmares while taking clonidine, or if you develop swelling in your feet or legs, paleness or coldness in your fingertips or toes, or any persistent or bothersome side effect.
Apply the transdermal patch to a hairless area of skin such as the upper arm or torso. Use a different skin site each time. If the patch becomes loose, apply the supplied adhesive directly over it. If the patch falls off before 7 days are up, apply a new one. Do not remove the patch while bathing.
If you forget a dose of oral clonidine, take it as soon as possible and then go back to your regular schedule. If you miss 2 or more consecutive doses, consult your doctor; missed doses may cause blood pressure increases and severe adverse effects. Do not take a double dose.
Special Populations
Pregnancy/Breast-feeding: Clonidine passes into the fetal bloodstream. Animal studies show that clonidine may damage the fetus in doses as low as 1/3 the maximum dose. When this drug is considered crucial by your doctor, its potential benefits must be carefully weighed against its risks.
Clonidine passes into breast milk. Nursing mothers who must take this drug should use infant formula.
Seniors: Seniors are more susceptible to the effects of this drug and should begin with lower doses.

Generic Name
Clopidogrel (kloe-PID-oe-grel) nQ
Brand Name  Plavix
Type lul Drug Antiplatelet.
Prescribed For
Heart attack and stroke prevention; also used for blood thinning after placement of a vascular stent.
General Information
Artery-clogging blood clots are often the cause of heart attacks and strokes. clopidogrel reduces the risk of both by helping prevent blood-clot formation. This drug thins the blood by making platelets—the cells that aggregate to form clots—less “sticky.” It starts working in as little as 2 hours after taking a single tablet. The drug’s blood-thinning effect lasts until inactivated platelets are replaced by the body. Studies suggest that clopidogrel is more effective than aspirin in preventing heart attack and stroke in people at risk. People taking clopidogrel after scent surgery usually take it for a relatively short period. Those taking it to prevent a heart attack or stroke must take it for life.
Cautions and Warnings
Do not take clopidogrel if you are allergic or sensitive to any of its ingredients or to ticlopidine, a related antiplatelet. These drugs can rarely cause a rapid drop in white-blood-cell count.
People with bleeding ulcers, brain hemorrhages, or other bleeding problems should use clopidogrel with caution.
Thrombotic thrombocytopenic purpura (TTP) is a rare but serious complication of clopidogrel, sometimes reported after less than 2 weeks of treatment. See your doctor right away if you develop a sudden fever, unusual bruising, nosebleeds, bleeding gums, or any other unusual symptoms. TTP reduces your platelet count, interfering with blood clotting, and affects white-blood-cell count.
People with liver problems should use clopidogrel with caution.
Possible Side Effects
✓    Most common: rash and other skin problems.
✓    Common: chest pain, accidents, flu-like symptoms, pain, headache, dizziness, abdominal pain, upset stomach, joint pain, back pain, black-and-blue marks, and respiratory infection.
✓    Less common: tiredness, Swollen arms or legs, high blood pressure, diarrhea, nausea, bleeding, nosebleeds, breathing difficulties, runny nose, coughing, bronchitis, high blood cholesterol, urinary infection, and depression.
✓    Rare: bleeding in the brain and stomach ulcer. Contact your doctor if you experience any side effect not listed above.
Drug Interactions
•    Clopidogrel may interfere with the body’s ability to break down fluvastatin, nonsteroidal anti-inflammatory drugs (NSAIDs), phenytoin, tamoxifen, tolbutamide, torsamide, and
warfann.
•    Combining clopidogrel and NSAIDs may increase blood loss and bleeding in the stomach and intestines.
•    Do not combine clopidogrel and other antiplatelet drugs or
the anticoagulant (blood thinner) warfarin unless you are
under your doctor’s direct supervision. This interaction may
prevent normal blood clotting and lead to severe bleeding
problems.
Food Interactions
Clopidogrel may be taken without regard to food or meals.
Usual Dose
Adult: 75 mg a day.
Overdosage
Little is known about the effects of clopidogrel overdose aside from reduced blood clotting. Overdose victims should be taken to a hospital emergency room. ALWAYS bring the prescription bottle or container.
Special Information
Minor cuts may take longer to stop bleeding during treatment with clopidogrel. If you are having surgery, make sure your doctor knows you are taking clopidogrel. You may have to stop taking the drug I week before surgery.
If you forget a dose, take it as soon as you remember. If it is almost time for your next dose, skip the forgotten dose and continue with your regular schedule.
Special Populations
Pregnancy/Breast-feeding: The safety of using clopidogrel during pregnancy is not known. Other antiplatelet drugs, tike aspirin, are not used during pregnancy due to their possible effects on Mrjlher and fetus. When this drug is considered crucial by your doctor, its benefits must be carefully weighed against its risks.
Clopidogrel may pass into breast milk. Nursing mothers who must take this drug should use infant formula.
Seniors: Seniors may take this drug without special precaution.

Generic Name
Clorazepate (klor-AZ-uh-pate) 99
Brand Names
Gen-Xene    Tranxene-SD
Tranxene    Tranxene T-Tab
Type of Drug
Benzodiazepine sedative.
Prescribed For
Anxiety, tension, fatigue, and agitation; symptoms of acute alcohol withdrawal; partial seizures; also prescribed for irritable bowel syndrome and panic attacks.
General Information
Clorazepate dipotassium is a benzodiazepine. Benzodiazepines directly affect the brain. They can relax you and make you more tranquil or sleepier, or they can slow nervous system transmissions in such a way as to act as an anticonvulsant. Many doctors prefer benzodiazepines to other drugs that can be used to similar effect because they tend to be safer, have fewer side effects, and usually work as well, if not better.
Cautions and Warnings
Do not take clorazepate if you are allergic or sensitive to any of its ingredients or to another benzodiazepine drug, including clonazepam.
Clorazepate can aggravate narrow-angle glaucoma, but you may take it if you have open-angle glaucoma and are receiving therapy for it.
Other conditions in which clorazepate should be avoided are: severe depression, severe lung disease, sleep apnea (intermittent cessation of breathing during sleep), liver disease, drunkenness, and kidney diseaap_, to inOn of these conditions, the qq)NSSvve effects of clorazepate may be enhanced or could be detrimental to your overall condition.
Clorazepate should not be taken by psychotic patients because it is not effective for them and can trigger unusual excitement, stimulation, and rage.
Clorazepate is not intended to be used for more than 3-4 months at a time. Your doctor should reassess your condition before continuing your prescription beyond that time.
Clorazepate may be addictive. It should be used with caution in people with a history of drug dependence.
Drug withdrawal may develop if you stop taking it after as few as 4 weeks of regular use but is more likely after longer use. It may start with anxiety and progress to tingling in the hands or feet, sensitivity to bright light, sleep disturbances, cramps, tremors, muscle tension or twitching, poor concentration, flu-like symptoms, fatigue, appetite loss, sweating, and changes in mental state. Your dosage should always be reduced gradually to prevent drug withdrawal symptoms.
Possible Side Effects
Weakness and confusion may occur, especially in seniors and in those who are more sickly.
✓    Most common: mild drowsiness during the first few days of therapy.
✓    Less common: confusion, depression, lethargy, disorientation, headache, inactivity, slurred speech, stupor, dizziness, tremors, constipation, dry mouth, nausea, inability to control urination, sexual difficulties, irregular menstrual cycle, changes in heart rhythm, low blood pressure, fluid retention, blurred or double vision, itching, rash, hiccups, nervousness, inability to fall asleep, and occasional liver and kidney dysfunction. If you have any of these symptoms, stop taking the medicine and contact your doctor immediately.
✓    Rare: Rare side effects can affect your heart, stomach and intestines, urinary tract, blood, muscles and joints. Contact your doctor if you experience any side effects not listed above.
Drug Interactions
•    Clorazepate is a central-nervous-system depressant. Don’t mix it with alcohol, other sedatives, narcotics, barbiturates, monoamine oxidase inhibitor and other antidepressants, and antihistamines. Taking Clorazepate with these drugs may result in excessive depression, tiredness, sleepiness, breathing difficulties, or related symptoms.
•    Smoking may reduce clorazepate’s effectiveness by in-
creasing the rate at which it is broken down by the body.
•    Clorazepate’s effects may be prolonged when it is mixed with cimetidine, contraceptive drugs, disulfiram, fluoxetine, isoniazid, ketoconazole, metoprolol, probenecid, propoxyphene, propranolol, rifampin, or valproic acid. Theophylline may reduce clorazepate’s sedative effects.
•    If you take antacids, separate them from your clorazepate dose by at least 1 hour to prevent them from interfering with the absorption of clorazepate into the bloodstream.
•    Clorazepate may increase blood levels of digoxin and the chances of digoxin toxicity.
•    The effect of levodopa + carbidopa may be decreased if it is taken together with clorazepate.
•    Combining clorazepate with phenytoin may increase phenytoin blood concentrations and the chances of phenytoin toxicity.
Food Interactions
Clorazepate is best taken on an empty stomach, but it may be taken with food if it upsets your stomach.
Usual Dose
Immediate-Release
Adult and Child (age 9 and over): 15-60 mg daily. The average dose is 30 mg in divided quantities, but dosage must be adjusted to individual response for maximum effect. Maximum recommended daily dose is 90 mg. For treatment of anxiety, clorazepate may be taken as a single dose at bedtime.
Child (under age 9): not recommended.
Sustained-Release
Adult: The sustained-release form of clorazepate may be given as a single dose, either 11.25 or 22.5 mg, once every 24 hours. Sustained-release tablets are not recommended for the initial dosage.
Child: not recommended.
Overdosage
Symptoms of overdose are confusion, sleepiness, poor coordination, lack of response to pain such as a pin prick, loss of reflexes, shallow breathing, low blood pressure, and coma. The victim should be taken to a hospital emergency room. ALWAYS bring the prescription bottle or container.
Special Information
Clorazepate can cause tiredness, drowsiness, inability to concentrate, or similar symptoms. Be careful if you are driving, operating machinery, or performing other activities that require concentration.
People taking clorazepate for more than 3 or 4 months at a time may develop drug withdrawal reactions if the medication is stopped suddenly (see “Cautions and Warnings”). Do not stop taking clorazepate or increase or decrease your dosage without first consulting your doctor.
If you forget a dose of clorazepate, take it as soon as you remember. If it is almost time for your next dose, skip the dose you forgot and continue with your regular schedule. Do not take a double dose.
Special Populations
Pregnancy/Breast-feeding: Clorazepate may cause birth defects if taken during the first 3 months of pregnancy. Avoid this drug if you are or might be pregnant.
Clorazepate may pass into breast milk. Nursing mothers who must take clorazepate should use infant formula.
Seniors: Seniors, especially those with liver or kidney disease, are more sensitive to the effects of clorazepate and generally require smaller doses to achieve the same effect.

HEADACHES AND MIGRAINES

Wednesday, July 22nd, 2009

HEADACHES AND MIGRAINES
• Take aspirin or acetaminophen for an occasional tension headache
• Don’t overuse headache medication
• Consult a doctor if headaches are frequent or severe
• Experiment with riboflavin or feverfew for natural migraine prevention
• Try acupuncture treatments to reduce migraine frequency
• Treat a migraine as early as possible
• Use Excedrin Migraine for mild migraines ****
• Ask your doctor about a W Aan for more severe
• Discuss topiramate (Topamax) with your MD if you suffer frequent migraines
• Prevent menstrual migraines with NSAIDs
• Prevent sex headaches with NSAIDs
Headaches are extraordinarily common,number seven on the list of reason-, why people see their doctor taking of wellbutrin xl and zoloft . It is estimated that 45 million people suffer from ChTonic’head pain cortico steroids negatively affect male testosterone .That doesn’t begin to include those who have occasional headaches zyprexa quick dissolve . Yet for all that, the exact causes of head pain are not all that clear hydroxyzine pamoate and faq .
According to Joel Saper, MD, director of the Michigan Head Pain and Neurological Institute, the brain itself doesn’t feel pain premarin hair loss . That’s why neurosurgeons can operate on the brain tissue while a patient is wide awake carbatrol kidney . So, a headache isn’t exactly the result of pain in the brain direction flomax taking . We perceive head pain that may originate from the scalp, the skull, or the coverings of the brain buspar wiki . Muscles and nerves in the neck can also create discomfort that is perceived as a headache buying valtrex .
An occasional mild headache does not usually pose a serious problem prilosec and bone loss . But a more severe headache, even if it occurs only once in a while, or a chronic headache, even if it is not extremely painful, deserves medical evaluation terazosin cns distribution . Popping a couple of aspirin or acetaminophen pills just isn’t a good idea when the headache occurs several times a week prevacid gastroesophageal reflux diease . In fact, Dr maxalt and high blood pressure . Saper says that using such over-the-counter (OTC) analgesics too frequently can actually cause the headaches you’re trying to treat who makes cytoxan . It takes an experienced headache doctor to help someone out of such a vicious cycle imuran and pancytopenia .
I have suffered from headaches all my life zovirax solution dosing information . For the past 30 years, I’ve taken from 25 to 35 aspirins daily, in addition to sinus medication creative and lithium batteries . My doctor doesn’t know about these large doses, but regular checkups reveal no damage to my liver or kidneys levothyroxine at night .
The trouble is that many physicians are not aware of how serious this problem can be dissolving penicillin powder . John Edmeads, MD, editorializing in the journal Headache, noted that “the daily use (or, more accurately, abuse) of analgesics actually worsened and perpetuated headaches,” He bemoaned the fact that so few physicians “know that chronic analgesic abuse causes chronic headaches natural viagra alternative review .”328
The diagnostic dilemma for doctors is that they must distinguish between headaches brought on by overuse of pain relievers, headaches caused by some other medical condition, and headaches caused by a change in brain chemistry buy wellbutrin 300 xl . If the headache is a consequence of an underlying condition like the flu, it will go away when the infection runs its course equate gas relief with infant motrin . Celiac disease is one condition that can cause recurrent headaches, among many other symptoms, although the underlying issue is actually a reaction to gluten in the small intestine side effects from ramipril tablets .The treatment is to avoid any foods that contain gluten (wheat, barley, and rye) prednisone and lysodren for do .
I suffered from migraine headaches for more than 10 years topamax side eftects . I saw several neurologists, but my intense headaches forced me to take early retirement viagra chemist nottingham .
In the fall 02002, 1 went from three headaches a week to almost nonstop compare prices nexium . That November, I had only 3 days without headaches fun facts about lithium . I took migraine meds like Frova, Maxalt, and Imitrex, but I mostly lay in bed in a dark room my doctor prescribed .3 premarin .
I was at my wit’s end fsh estradiol fertility . Then illy family doctor suggested a gluten-free diet viagra in india by mail order . Gradually my headaches became less frequent and after several months I was 98 percent headache-free buy famvir . I feel I have been given a new life!
Caffeine Withdrawal Headache
By now, many people recognize that daily use of caffeine can lead to a dependence on it zoloft stuffed animal . Stopping the caffeine—for example, by not drinking coffee on the weekends—can lead to a caffeine withdrawal headache, accompanied by irritability and fatigue plavix and diclofenac sodium contraindications . Probably the best way to deal with this type of headache in the short term is to get a little caffeine buy 200 mg generic lamotrigine . In the longer term, though, a more gradual withdrawal from coffee, soda, or caffeine-containing medications will allow a person to drop the use of the drug without the wicked headache hydrochlorothiazide and libido .
Q lamictal and weekness . 1 am a healthy person and rarely take any medicine loow priced nexium . I quit smoking 14 months ago and am trying to stop drinking coffee lithium polymer battery hyperion . Lately I’ve had trouble with fatigue and on headaches in the afternoon sarafem directons on usage . If I take Extra Strength Excedrin with a Coke on my break, the headache goes away like magic brethine licensing . Regular aspirin doesn’t work as well using hibiclens while on accutane . Why is Excedrin more effective?
A actos sales 2005 . Each Extra Strength Excedrin contains aspirin (250 mg), acetaminophen (250 mg), and 65 mg of caffeine lotrel drug interactions . That means that a standard two-caplet dose will pro-vide you with 130 mg of caffeine what is element lithium used for . Together with your cola, this probably provides as much caffeine as two mugs of coffee dangerous testosterone supplements .
It is conceivable that your afternoon slump and headaches are due to caffeine withdrawal finasteride 2 . People who customarily drink as little as 21/2 cups of coffee can experience symptoms such as lethargy, headache, and anxiety when they stop jaw necrosis actonel .
By taking a pain reliever that contains caffeine, you could be easing your withdrawal college pharmacy sublingual testosterone . An alternate solution is to try to reduce your caffeine intake gradually until you are completely weaned symptoms of prednisone overdose .
Tension Headache
Experts used to pigeonhole headaches into separate categories: tension headache, sinus headache, migraine, and so forth 18 takes viagra . While some categories may be useful, the separations between them have blurred should procardia be taken with food . Trying to tell a tension headache from a migraine is not for amateurs trileptal medication .
Although tension headaches are said to be far more common than migraines, much of the research lately has focused on migraine prevention and treatment oily skin returned accutane . How should you handle recurrent tension headaches, then?
As long as the headache does not occur more often than once a week, there is no problem with using the regular OTC headache pills or powders fsh levels decrease taking clomid .These may contain aspirin, acetaminophen, or a nonsteroidal anti-inflammatory drug (NSAID), usually ibuprofen took motrin while pregnant . All of these have been shown to ease headache pain minoxidil vs propecia . For this type of occasional use, the only reason to prefer one instead of another is based on your own experience of pain relief testimonials of zithromax healing polymyositis . If aspirin doesn’t seem to help but Tylenol does, go with the acetaminophen—and vice versa serum depakote level lab test .
Adding caffeine to the analgesic may help it work better side effects of soma . You can buy a pill that already contains caffeine, or you could take your aspirin, acetaminophen, or ibuprofen with iced tea or a cup of coffee what happens if you snort amitriptyline .
Readers have suggested a few unique approaches that might be worth consideration, though we don’t have any good evidence that they work blurred vision cymbalta . They are, at least, inexpensive and low risk and will not perpetuate headache even if someone gets carried away and uses them too often interpret ir spectra of caffeine .
People have tried applying a dab of peppermint oil to the forehead cheap depakote . Others have put Vicks VapoRub on their temples diovan hair loss . Using Vicks for a headache is strictly an “off label” use, just like so many of the other creative uses people have invented for VapoRub increasing amoxicillin dosage during . It contains menthol as one of its ingredients-, peppermint oil also contains menthol pseudoephedrine overdose symptoms . We’re not aware that menthol has special properties to help ease headaches, but it has been shown to alleviate the pain of sore muscles tadalafil generic . Perhaps it is doing something similar fora tension headache cialis western open .
I have enjoyed your columns about Vicks VapoRub fora variety of uses diflucan prescription without . Here’s one you may not have heard before clindamycin diarreah . A friend had a headache that would not go away testosterone levels in childhood . I told her to rub a dab of Vicks on her forehead prochlorperazine for migraines . She thought I was nuts, but it worked effexor success . She has been using it ever since cialis tadalafil tablets .
Some headache specialists have used relaxation training for people who suffer from chronic or recurrent headaches cymbalta use with bipolar disorder . This can help individuals who are willing to practice the technique, including teenagers who have frequent headaches at school singulair patent expiration .121
One very important point for people who suffer frequent Aspirin
Plain old generic aspirin, 650 milligrams (two tablets), will ease the pain of an occasional tension headache in most cases quitting seroquel . The danger is if the headache becomes more frequent crushed ibuprofen . Aspirin overuse increases the possibility of stomach irritation or ulcers and can also be associated with “rebound headache ibuprofen and miscarriage .” Regularly using aspirin (or acetaminophen) at least 2 days B week may increase the risk that the headache will become chronic because of the medication prozac works grat .
Side effects: Digestive tract upset, including ulcers Downside: People who are allergic to aspirin must avoid it completely itraconazole estrogenic effects .
Cost: Inexpensive, about 5 cents a dose aygestin in uterine bleeding . More if you buy a brand name misoprostol monograph .
headaches of any sort: Overusing pain relievers can actually cause chronic headache d nolvadex . This is a very difficult problem to handle alone, so a person who is using painkillers for a headache more than 2 days a week on a regular basis should get help from a headache specialist wellbutrin for adult adhd add .
Migraine Headache
Experts estimate that 28 million to 30 million Americans suffer from migraines pentoxifylline description .330 Many more migraine sufferers are women than men evista and cervical cancer . As we have pointed out, trying to distinguish between a migraine headache and some other cause of head pain is generally a job for an expert risperdal herb interactions . Usually, though, if the headache is accompanied by exceptional sensitivity to light or noise or by nausea, or if it is preceded by an aura of flashing lights or blind spots, a person should be evaluated for migraine effexor and monopoly . Other tip-offs might be pain on just one side of the head or pain that throbs, especially when you move soma holiday cd greenwheel .
We tend to think of migraines as crushingly painful can lasix hurt you . That’s not always the case response to accutane . But if it is a migraine, there are ways to treat it that should help get the pain under control, whether it is simply annoying or completely incapacitating cheap fluoxetine online order fluoxetine now .
Q tylenol and motrin interaction . 1 am 20 years old and have suffered with severe headaches for as long as I can remember wellbutrin and neurontin . Recently I asked my doctor about them, and he told me as long as / could stop them with an OTC pain medicine / shouldn’t worry about them migraine treatment natural imitrex .
/ am concerned about the frequency of the headaches and the fact that the pain is always on the left side of my head buy cheap generic prilosec . / suffer from at least one a week, usually more keflex suspension flavor . Which pain reliever is best?
A diflucan and nystatin and comparison . Please check in with a headache center alcohol and ampicillin . A one-sided headache could be a symptom of migraine premature ejaculation trazodone . If that is your problem, a prescription migraine medication might be helpful superiority of ofloxacin over ciprofloxacin .
According to Joel Saper, MD, one of the country’s leading experts on headache, using any OTC pain reliever more than 2 days a week might aggravate the problem by causing rebound headaches clomid out of system .
MIGRAINE TRIGGERS
Alcohol (including but not limited to red wine)
Aspartame (found in many “light” sugar-free foods) Caffeine withdrawal
Chocolate
MSG (monosodium glutamate, found in many processed foods, including peanuts)
Nitrates (found in processed meats like hot dogs and salami)
Tyramine (found in aged cheese, chocolate, nuts, sour cream, and yogurt)
0 0 0
If you are diagnosed with migraines, you will want to know what stimuli jump-start them so you can avoid them to the extent possible apri stock pick free high rollers . The migraine-prone brain likes to have a certain amount of routine avalide eps manchester . Disrupted sleep, dehydration, missed meals, secondhand smoke, perfume, and a number of different foods or ingredients are common triggers medication lawsuits norvasc . 33 1 Keeping a headache diary is a good way to figure out what things get your migraine going avodart diflucan . In it, you record details like meals, exercise, sleep schedule, and so forth, as well as your migraines, so you can track back for any patterns discontinue clomiphene citrate .
The validity of some of these suspected triggers has been questioned overdose and children’s motrin . The manufacturer of aspartame has produced data demonstrating that aspartame does not cause headaches doryx prescription . One double-blind study using carob candy as a placebo for chocolate found that women with recurrent migraines were no more likely to develop headaches when given chocolate than when given placebo depakote levels in children . 112 This news was greeted with relief bordering on glee in some circles luvox withdrawl symptoms .
0 * 0
Q usc estradiol study . My wife loves chocolate, but she read that it can trigger headaches panasonic lithium ion cordless wood combo . Now she won’t eat it, even on special occasions side effects with taking prednisone 10mg . I used to buy her great chocolate for Valentine’s Day and her birthday and she really enjoyed it sniffing risperdal .
I never remember her getting a headache right after eating chocolate, but she does occasionally suffer from migraines effects of caffeine on parkinson’s disease . Can you tell me why chocolate is a problem? -
A uses of sertraline . Chocolate has long been blamed for triggering headaches because it is high in tyramine which is better caduet or altace . This substance is thought to release serotonin and make blood vessels contract and expand clozapine and weight gain . But research shows that most headache sufferers may not be susceptible to chocolate atacand hct tablet .
In a carefully designed study, 63 female headache sufferers were given either carob or chocolate bars (both mint flavored to disguise the obvious difference) penicillin alchohol . There was no significant association of headaches with chocolate bar consumption metformin hdl .
Your wife might perform her own experiment to see if she really is sensitive to chocolate doxazosin 6mg . She may be depriving herself needlessly generic versions of zocor .
0 0 0
Some scientists doubt that cheese, chocolate, and nuts are actually migraine triggers was is nortriptyline used for . Even if they are not migraine triggers for most people, some individuals may react to aspartame, chocolate, cheese, or any of a number of other foods hypertension and drugs and accupril .
Have you ever heard of sipping beer to stop a migraine? I went to a doctor in a little town in Louisiana, and he asked if I get an aura carmen allegra md . Before my head starts to hurt, my vision changes and I see little blinky lights levitra in women .
The doctor said / should drink a can of beer (not wine or liquor) as soon as I start to see the lights exelon web mail . Over the last 20 years, this remedy has worked almost every time bactrim prostate specific . / thought some other migraine sufferers would like to know fenofibrate 10 mg .
The 10 predict what foods will trigger a migraine for one person or be helpful for another caffeine and gluten-free diet . Beer is thought to cause headaches for some people warfarin in bulk . But we heard from one woman that if she drank a beer at the very first sign of trouble, the headache never materialized buying generic viagra . She even traveled with an emergency can for medicinal purpose-, The headache diary we mentioned will help you sort out what foods create problems for you depakote er effects on learning .
I have suffered with migraines all my life, but in the Iasi few years they got worse zanaflex snort . My medicine stopped working and I had headaches
every day buy caffeine free dr pepper .
I was desperate, so when someone suggested I see an allergist
did ibm thinkpad x lithium battery . I discovered I am allergic to a lot of foods I ate every day, includ-
ing coffee, wheat, rice, oats, eggs, and tomatoes dr robert bae in lithium .
Now that I have changed my diet, my head is much better seroquel recreational . Some
recurrent migraines warrant seeing an allergist doxycycline stomach pain .
Natural Remedies
The real action in migraine treatment is with the “triptan” prescription drugs that have been developed over the past decade coming off of cymbalta . There is also an interesting advance in a prescription drug to be taken preventatively by those who suffer chronic migraines zoloft and ginseng . But some herbal remedies and dietary supplements have shown promise in preventing migraines, too simvastatin teva side effects .
RIBOFLAVIN
I’ve had migraines for many years atarax 10 ml . I think I’ve taken every migraine drug on the market and even ended up in the emergency room a few times quinapril 0.5 mg .
I was finally sent to a neurologist who told me to take vitamin B complex (B-100) comprar el viagra gen rico .1 can honestly say I have not had a migraine headache in 2 years vytorin lawsuit north carolina . I couldn’t believe after so much time taking drugs that all I needed to do, was take a vitamin ibuprofen and water retention .
Riboflavin, a B vitamin (B), has been reported to help prevent migraine recurrences the mefloquine antiparasitic . One study found that 400 milligrams of riboflavin per day was able to reduce headache frequency markedly, from 4 days a month to 2 days a month synthroid drip .333 This is a very high dose, however lithium battery aa . Another study compared a product that combined 400 milligrams of riboflavin with 300 milligrams of magnesium and 100 milligrams of feverfew extract to a “placebo” of 25 milligrams 01 Tibofiavin lisinopril bactrim harmful interaction .31The researchers found no difference between the placebo and the combination product dexamethasone acoustic trauma . Nevertheless, the scientists weren’t disappointed because both groups had fewer migraines and less overall discomfort than they had had before starting the study naproxen risks .The investigators hypothesized that 25 milligrams of riboflavin might have been enough to help reduce migraines, which would have explained the lack of difference between the placebo and the tested preparation allegra-d dissolve .
Q valsartan hctz . I’ve read that riboflavin, feverfew, and magnesium can help prevent migraines pravachol effects sex drive . But finding all these things and taking multiple products can be difficult seroquel drug information . All three are contained in an OTC product called MigreLief prednisolone weight gain .
I am a 31-year-old female who has suffered from migraines for many years pharmacy glucophage . Two or three migraines a week really interfered with my life clemastine and betamethasone . I would make plans and then at the last minute I would have to cancel due to another migraine soma sujanani .
This was an ongoing problem what is celebrex for depression . Even after numerous doctor visits and many prescription medicines, I never got relief celexa ocd .
When I decided to try MigreLief as a more natural approach, I had fewer headaches within a month cipro side effecs . In a couple of months my migraines disappeared almost completely eye bleeding coumadin .
A metformin avandia . Thank you for bringing this product to our attention prednisone porstate cancer . The manufacturer, Quantum, points out that MigreLief is intended only for headache prevention and not for immediate pain relief the side effects for lexapro . We have not seen a placebo-controlled trial of this combination product, although there is some research to support the use of each of the ingredients for migraine prevention indian cialis .

Drugs for Diabetes Treatment.

Monday, July 20th, 2009

FENUGREEK
Fenugreek is a seed used to spice Indian food compare diovan and cozaar . It has also been used in traditional medicine to treat symptoms that indicate diabetes saturday delivery tramadol . Studies done in humans suggest that it can be used in
well
type 1 as as type 2 diabetes in addition to,prescribed medi-
cation women excess testosterone . The powdered seed lowered blood sugar and HbAlc feline hypertrophic cardiomyopathy prednisone . 249
There are potential side effects, however zovirax insert . Fenugreek can cause diarrhea, flatulence, and allergic reactions celexa testimonies . It might, in theory, interact with warfarin (Coumadin) or other anticoagulant medicines and probably should be avoided by people who take them trazodone for bipolar . There is always a possibility of hypoglycemia when blood sugar–lowering botanical medicines are added to prescription drugs for blood sugar control, so careful monitoring is essential rx neurontin . The usual dose is around 1 or 2 grams of seeds three times a day, but it may also be taken as a tea 250
* 0 *
G atenolol personality changes . I found a spice in my spice rack that I had never heard of, and I had no instructions on how to use it lack of response to furosemide . I looked up fenugreek as a spice and found that it is a medicinal herb celebrex chemotherapy colon cancer .
It is used to lower cholesterol and control blood sugar provera for bodybuilders . The only side effect I found is nausea if you take too much specific heat lithium . What do you know about this herb? -
A adderall and selegiline together . Studies in animals and humans show that fenugreek can lower cholesterol and blood sugar methyl prednisone acetate . If diabetics take fenugreek, they should monitor their blood sugar to make sure it doesn’t fall too much xeno lithium .
Fenugreek seeds are rich in soluble fiber and can be used to treat constipation paroxetine heart rate . At high doses, this herb can cause digestive distress evista floaters in eyes .
o 0 *
GYMNEMA SYLVESTRE
This herb comes from India and has been used in traditional Ayurvedic medicine for centuries ms avoiding caffeine . Animal studies have demonstrated that it is capable of lowering blood sugar viagra lasting .”‘ No serious side effects have been reported, but perhaps the scarcity of well-controlled clinical trials explains that to some extent canadian pharmacy bupropion .
NOPAL (Opuntia sp caffeine in tea bags .)
One interesting botanical treatment has only a little bit of research to support it, but it is becoming increasingly popu-far viagra photo woman . We heard several years ago from a physician who said one of his diabetic patients had improved his blood sugar control with prickly pear tea side effects of stopping tamoxifen . This cactus, called nopal in Mexico, has been studied primarily in animals beta celexa citalopram interferon lyrica pregabalin . That research indicates that the cactus can help lower blood sugar fosinopril solium . 252,253 Research in humans is preliminary, but it suggests that nopal may also be useful in helping to control blood sugar in type 2 diabetes united states wellbutrin bupropion hcl . 254 Close monitoring and medical supervision are advised zithromax ear book .
lama family practitioner and want to share an herbal remedy with you allopurinol and blood pressure . A 60-year-old male Hispanic diabetic patient has had trouble controlling his blood sugar ovulation pain with clomid . Despite intensive diet changes and a prescription for Glucovance, his blood sugar still ran around 160 to 100-plus testosterone treatment and prostate cancer .
One day he came in with his diary showing consistent blood sugars of 90 to 100 fexofenadine solubility in isopropylalcohol . I asked what he was doing differently and he said in a low voice, “I’ve got a new girlfriend from Mexico online fexofenadine . She makes me tea from nopalito [prickly pear> cactus and has me drink it three times a day advil motrin recalls . Now my sugars are doing better buy celecoxib low cost . -
Finding fresh nopal cactus outside of Mexico or the desert of the southwestern United States could be tricky loratadine 180 . When we shared the story about nopalito tea (nopalito is a young stem segment from the cactus), we were inundated with questions from readers who wanted to know how they could get some nopal cactus leaves does prednisone cause sterility . Short of moving, you might try looking for this natural plant product in your local health-food store (or on the Web) voltaren info . Although it is unlikely you will find fresh leaves, you will be able to locate capsules labeled prickly pear cactus (Opuntia) or nopal cactus avandia zantac .
Careful blood sugar monitoring is essential age testosterone . One reader who blended cactus with apple juice kept careful track of his cholesterol levels, triglycerides, and glucose bladder infection ibuprofen . In 6 months, his triglycerides dropped from 191 to 139 and his total cholesterol went from 202 to 169 web md doxepin . More interesting, his blood glucose drifted down as well seafood allergies and atrovent . Here is his account:
I read your article about nopalito tea, so I started using cactus in April and had good results what’s the main resources of caffeine . My doctor knows about it zithromax for oral suspension . I blend one bag of cactus and 3 112 cups of apple juice into a drinkable liquid effexor memory . I drink 4 ounces three times a day mens viagra . Here are my results why is caffeine bad in pregnancy .
Blood Glucose (average)
Jan 147 no cactus
Feb 143 no cactus
Mar 158 no cactus
Apr 142 with cactus
May 132 with cactus
Jun 126 with cactus
Jul 135 with cactus
Aug 128 with cactus
I write down every food I eat every day and take my test every morning and keep a record of it natural alternative to caffeine . I can see which food does what, and I take my medicine as always and my doctor has been kept informed battery lithium watch .
This gentleman is the poster child for responsible blood sugar control doxycycline burns treatment . Not only is he tracking his sugar levels carefully, he is also working closely with his physician to make sure what he does is safe and effective amsterdam nederlands sildenafil .
STEVIA
Stevia (Stevia rebaudiana) is a nonsugar sweetener derived from the leaves of a South American shrub phenytoin effects lab values . It is not approved as a sugar substitute in the United States but is frequently used in Japan didanosine causing lipoatrophy . Some preliminary research suggests that using stevia instead of sugar might have a benefit beyond simply not consuming sugar on levoxyl but still having symtoms . A small study in Brazil found that stevia tea could improve glucose tolerance in nondiabetic individuals simvastatin 80mg tablet . 255 The plant can also lower blood pressure celexa twice normal dose . No significant toxicity has been reported do cardiologists order toradol .
Stevia is a natural sugar substitute fosinopril side effects . In addition to sweetening food and drinks without raising blood sugar, stevia may be capable of improving glucose tolerance 1 2 aa lithium 3.6v battery . Be sure to monitor your blood sugar when adding this sweetener to a medication regimen automobile lithium ion battery .
Downside: In laboratory tests, high doses of stevia interfered with animals’ reproduction ketorolac pediatric .
Cost: Approximately 10 or 20 per serving Easing Stress
There is a direct connection between your level of stress and your blood sugar paroxetine and . For someone without diabetes, this is probably no big deal, unless you are always under stress warfarin metallic taste . But for a diabetic, anxiety, fear, depression, and emotional pressure will boost blood sugar and make the condition harder to control lyrics for lithium .211,2″ Giving a speech, having a fight with your partner, or going in for your annual performance review at work can all affect your stress level and your blood sugar singulair and weight loss . Doctors often look at diet, exercise, and other physical factors ibuprofen crush . They are less likely to consider emotions, even though they have such a profound impact on a diabetic’s health novartis v pfizer zithromax .
How can a diabetic learn how to manage stress successfully? There is no cookie-cutter answer to this question is cipro sulfa based . Everyone handles stress differently phenergan sudaphed contraindication . For some, the only effective strategy might be to quit a highly demanding job and move to a cave decadron for oral surgery . Doing that would stress others out even more preparation of ethinyl estradiol . Finding the right approach may take trial and error xenical caps orlistat roche .
Avoiding people who make your hands cold is a good place to start hartford zyprexa attorneys . Buy a mood ring (a relic of the 1970s) aluminum lithium etchant . It reacts to skin temperature viagra side effects diarrhea . Whenever your hands get cold as a response to stress, you should do something different from your current activity to warm them up decadron contain only t4 . Relaxation tapes can be helpful if you can carve out time to listen lithium arizona . Our favorites are by Emmett Miller, MD chemical composition of neuronal soma . Dr felodipine reaction . Miller has been in this business a long time and has a soothing voice 7 day doxycycline symptoms disappear . We guarantee that if you listen to his Letting Go of Stress, you will be more relaxed afterward viagra levitra cialis comparison .
Some people may benefit from individual psychological counseling or biofeedback training to learn to cope with stress prednisolone hot flashes . But others may be able to find a group that is learning stress management techniques accutane colitis . 251 If you need a guide to doing it yourself, we suggest you look for a copy of Richard Surwit’s book, The Mind-Body Diabetes Revolution requip and compulsive gambling . It has some good
DR what does bactrim treat . MILLER’S SOOTHING SOUNDS
To purchase Dr metformin 500 571 . Miller’s CDs or tapes, you can visit his Web site, www topical oinment chloramphenicol .DrMiller methotrexate how long .com, or call 800-52-TAPES omnicef stomach . Letting Go of Stress or the Ten-Minute Stress Manager is a good starting place celebrex docing information .
tips on learning to relax and overcome stress as well as background on the importance of psychological issues in diabetes citalopram hydrobromide capsules .
When all else fails, an antianxiety agent can be surprisingly effective at controlling blood sugar in the short term remeron childrens studies . If, for example, you know that traveling makes you anxious and throws your blood sugar out of kilter, you may want to ask your doctor whether a short course of diazepam (Valium), alprazolam (Xanax), or some similar medicine might help you deal with the hassle of travel no prescription claritin .259 Such drugs can be habit-forming, however, so relying on them for long periods of time is not desirable veetids expire .
Depression also has a major impact on diabetes and messes up efforts to keep blood sugar where it should’be information about nexium . Everything feels much harder to manage when you’re down in the dumps, and your attention to exercise, diet, medication, and self-care may well suffer viagra doseages effects . Changes in brain biochemistry associated with depression might also contribute directly to a higher risk of diabetes complications lithium battery explosions . MO Blood clots leading to heart attacks or strokes are more likely when diabetics are depressed; so are irregular heart rhythms and inflammation methotrexate factoids . It’s just as crucial for a diabetic to be evaluated regularly for depression, and to get treatment when it is needed, as it is for her to get regular eye exams and foot care prostatitis and flomax .
Pills to Lower Blood Sugar
Quite often, diet and exercise alone are not enough to control blood sugar glyburide 2 mg . There is a bewildering array of medicine the doctor may prescribe: metformin, which also is dispensed under the brand name Glucophage; medicine with “glitazone” in the generic name, like pioglitazone (Actor); and old-fashioned blood sugar—lowering drugs similar to chlorpropamide or tolazamide, or their newer cousins glyburide (Micronase), glimepiride (Amaryl), or glipizide (Glucotrol) zoloft causing cardiac arrythmias . Newer drugs that stimulate insulin secretion, called nateglinide (Starlix) and repaglinide (Prandin), might be used instead of one of the older blood sugar—lowering drugs levaquin diflucan interactions . Eventually, if blood sugar and glycosylated hemoglobin can’t be brought down to acceptable levels, even type 2 diabetics may end up using insulin bacterial vaginosis flagyl did not work . But it usually makes sense to try oral medicines first metaloproteinase cipro .
It is difficult to tell which of these pills would work best for any given patient hold dose metoprolol . As with everything else pertaining to diabetes, people vary in their responses salbutamol and hyperstimulation . Some do well on a single drug, while others need a complicated regimen class action lawsuits against provera . Only you and your doctor can determine which medication(s) are likely to be safest and most effective for you amoxicillin dental work .
To try to sort out the patterns and give doctors some guidance, scientists at Kaiser Permanents, an enormous HMO in northern California, reviewed the organization’s vast database efficacit gel testosterone 50mg j . First they created a registry of the diabetic patients, and then they examined the data to see which drugs were most effective over time male devo provera . Even though most patients are started on one of the medicines like chlorpropamide or glyburide, this was the least effective treatment for getting HbAl down to
target personal experiences of people on wellbutrin .261
The most effective treatment was triple therapy: a
“glitazone”-type drug in combination with metformin and a drug like glyburide onset action lamictal days . Next best after that was metformin together with insulin pepcid indication gi protect .
One of the most interesting features of the Kaiser Permanents study was that patient behavior could be used to predict success, aside from the drug used hydroxyzine helps withdrawls of opium . Patients who monitored their blood sugar frequently and those who kept all or nearly all of their appointments were significantly more likely to get their blood sugar under control and keep it there clomipramine hcl tablets and alcohol . 262 Making sure that you are on top of your diabetes treatment, taking your medication, monitoring your blood sugar, keeping track of HbA, following a sensible diet and exercise regimen, and controlling your weight as much as possible may be nearly as important as which drugs your doctor prescribes atomoxetine medication diaes .
Metformin (Glucophage)
A review by the Cochrane Collaboration of most of the world’s diabetes literature shows that metformin (Glucophage) alone, if used to keep blood glucose under tight control, is an excellent treatment inderal la medicine .263 Metformin improves blood sugar control by improving the cells’ response to insulin and reducing the amount of sugar that the liver makes risperidone weight gain . Unlike some other oral diabetes drugs, it doesn’t lead to weight gain and may even help people get their weight under control amitriptyline mylan .
It can be dangerous, however, for people with kidney disease testosterone replacement therapy cycles . They should not take the drug, and everyone on metformin should have their kidney function monitored regularly (at least once a year) altace absorption . People with congestive heart failure should not take metformin, either sulfamethoxazole ds tabitp .
SYMPTOMS OF LACTIC ACIDOSIS
• Muscle aches or weakness
• Shortness of breath
• Stomachache, nausea, or vomiting
• Lethargy or drowsiness
• Irregular heartbeat
• Feeling generally awful
Metformin has two nasty side effects that patients must know about drugs and norvasc . One, lactic acidosis, is rare, but it is a medical emergency if it occurs villa allegra . Lactic acidosis can be lethal estrace homrmone . People with kidney disease or congestive heart failure are more susceptible to this problem, which is why they must not take metformin hormone replacement therapy weight premarin . Otherwise healthy diabetics might also develop lactic acidosis on metformin, especially if they drink alcohol watermellon viagra .
What makes metformin so tricky is that patients frequently experience digestive tract distress when they first start taking this medicine tramadol ships next day apo . Side effects can include diarrhea, nausea, vomiting, indigestion, and stomachache accutane atlanta attorney . After several weeks, however, these side effects should fade away strattera testimonies . If digestive symptoms
*** Metformin (Glucophage)
Metformin improves insulin sensitivity caffeine and hunger . It may control blood sugar alone or be combined with other diabetes drugs to improve blood sugar control attack heart ibuprofen . Common side effects include diarrhea, nausea and vomiting, flatulence, fatigue, indigestion, and headache intas strattera for sale online .
Avoid guar gum in low-fat foods (salad dressing, frozen desserts, etc depo provera transexual drug .), because it reduces metformin’s absorption and effectiveness is prevacid an nsaid .
Downside: Lactic acidosis, a rare reaction, requires emergency medical attention and can be fatal nifedipine ointment preparation .
Cost: Approximately $90 to $120 per month; generic $65 to $100
recur, they must be brought to the doctor’s attention immediately since they might be symptoms of lactic acidosis ct scan heart and lopressor .
The other side effect is depletion of vitamin B12 snorting bupropion . Because this vitamin is stored in the body, the depletion is gradual and the symptoms either may not be noticed or may be attributed to some other cause can lovastatin subscriptions cause cough . The physician should test for methylinaIonic acid (MMA) as well as for vitamin B,2 levels compare kytril and zofran . Fortunately, it is easy to treat vitamin B12 deficiency with supplements birth defect imuran . The vitamin does not need to be injected in such cases; oral supplements of around 1 milligram daily (a large dose of vitamin B12) will work prednisone before surgery . Do check with your doctor to find out if this is appropriate for you sten testosterone .
I am a retired physician with type 2 diabetes metoclopramide and dialysis . Metformin has kept my blood sugar in the normal range for 10 years malassezia ketoconazole dog . Despite good control of my blood glucose and glycosylated hemoglobin, my foot numbness was getting worse warfarin back pain . I was also a tilde unsteady on my feet though it was very subtle flomax pseudoephedrine .
I reviewed the medical literature and discovered that metformin interferes with vitamin B1, absorption fertility insemination estrace uterine lining . I suspected I might be deficient in this vitamin, and I started taking oral vitamin B,
Within a week, I noticed that my mental capacity was sharper combivir and other antivirals . I had not realized before this that I was having any cognitive problems new england journal of medicine lipitor . I stopped having any trouble walking, and my foot numbness has decreased effects effexor alcohol .
Many older diabetics take metformin doxycycline cellulitis . ff they developed subtle neurological and mental deficits as a result of lack of vitamin B,, these problems could be treated but may well be overlooked zoloft vs xanax .
Pioglitazone (Actos)
Pioglitazone (Actos) is a newer diabetes medicine that increases insulin sensitivity and decreases insulin resistance aldactone for treating acne . These actions reduce the amount of insulin in the bloodstream and should lower HbAl rash from paxil . Not only can this medication bring fasting blood sugar down, it can also help control blood sugar levels after meals 1 4 propecia .” In the Kaiser Permanents study mentioned above, drugs in this class were the medications most likely to get HbA,, down to normal range by themselves lithium ion battery car fire .
Actos has received a lot of attention from doctors who specialize in treating diabetes es because it has a favorable im- pact on some blood lipids vytorin side effects muscle pain . It doesn’t seem to do much for Pioglitazone (Actos)
Pioglitazone improves insulin sensitivity’and decreases insulin resistance reference range estradiol . It lowers triglycerides and raises HDL, which might result in a lower risk of cardiovascular problems viagra and reduced ammunity . It is taken once a day escitalopram with titration .
Downside: May interact with oral contraceptives to make them less effective
Cost: Approximately $100 to $115 per month
bad LDL cholesterol, but it raises good HDL cholesterol (no mean feat) and lowers triglycerides atrovent peanut . 265
No one knows if these improvements in blood fats will result in a lower risk of heart attack or other cardiovascular complications in the long run gabapentin gaba . That, after all, is the really important issue, since diabetics are at such high risk of cardiovascular catastrophes ibuprofen versus rofecoxib . But Actos is fairly effective in preventing the closing up of a cardiac stent after it is put into a coronary artery study volunteers for topamax and alcohol .266 And a head-to-head study of Actos and Avandia (a similar medication) showed that Actos has a better effect on several measures of cholesterol and blood lipids ibuprofen liquid mg per ml . 261 If this translates down the road into reducing the likelihood of a heart attack or stroke, it would certainly be worthwhile allopurinol lab hahnemann .
Pioglitazone can cause fluid retention and as a result is not appropriate for use by patients with congestive heart failure lotrel azor . Side effects include a greater susceptibility to sore throats, colds, bronchitis, and the like; headaches; toothaches; sinusitis; and muscle pain allegra beach resort . A competing drug, rosiglitazone (Avandia, Avandamet), has also been linked to fluid retention celexa cs zoloft . More worrisome, though, is the possibility that this drug may contribute to fluid accumulation in the back of the eye purpose of flagyl .This macular edema could lead to blurred vision and eye damage claritin and cold medicine .
Repaglinide (Prandin)
The goal of treating diabetes is to keep blood sugar within the normal range, because that reduces the likelihood of serious complications prozac overdose nuerological damage . If you can’t achieve this with metformin or one of the “glitazones,” the doctor may add a medicine to stimulate the secretion of insulin lamictal and sunburn . Two drugs, nateglinide (Starlix) Repaglinide (Prandin?
Repaglinide lowers blood sugar by stimulating insulin release and is especially effective for reducing blood sugar following a meal cellcept indications . Repaglinide is taken before meals, usually within 15 minutes before beginning to eat can zovirax treat epstein barr virus .
Downside: Blood sugar may fall too much (hypoglycemia) brompheniramine and pseudoephedrine extended release . Repaglinide may contribute to weight gain caffeine memory .
Cost: Approximately $130 to $140 per month
and repaglinide (Prandin), make beta cells in the pancreas pump out more insulin at mealtime edward drummond m d and cymbalta . 268 This helps keep blood glucose levels from going too high after eating effexor ejaculation .
Some studies have compared these two medicines alone or in various combinations scarring accutane . The results aren’t definitive, but comparing nateglinide alone to repaglinide alone suggests that there is an advantage to repaglinide whats stronger than ultram .269 Prandin lowered HbA, signifi- cantly more than Starlix did; it brought down fasting blood sugar better; and more than half (54 percent) of the patients on Prandin were able to get their HbA below 7 percent, whereas fewer than half (42 percent) of those or Starlix managed that osteoporosis lamotrigine . Of course, there’s a price amitza or zelnorm . Patients on Prandin were more likely to suffer from hypoglycemia (low blood sugar) rimonabant effect on abdominal fat . They also gained more weight (almost 4 pounds in 4 months), a discouraging side effect patient assistance program for accutane . -
These drugs are more effective in combination with metformin than they are on their own memory loss zoloft . 270 tricor cholesterol statin .27L272 Side effects of repaglinide include headache, joint or back pain, and tipper respiratory infection no prescription needed glyburide . Drugs such as ketoconazole (Nizoral) and clarithromycin (Biaxin) boost blood levels of repaglinide, and that could increase the likelihood of unpleasant reactions 2cialis compare levitra . Grapefruit affects the same enzyme (CYP3A4) and might have a similar effect side effects of mircette .
Exenatide (Byetta)
Exenatide (Byetta) is another treatment option for type 2 diabetics prograf pronounced . It has an interesting history zoloft user review . because it got started with research into the saliva of a poisonous Southwestern lizard called a Gila monster what is lexapro medicine . Byetta is injected and is used in combination with metformin or a blood sugar–lowering drug like glyburide claritin d warnings . Byetta reduces the bump in blood sugar after meals and can help diabetics lose weight kidney infection cipro .
The most common side effect is nausea, but the most serious is hypoglycemia sustiva drug . Adding Byetta to a medicine like glyburide increases the risk of a dangerous drop in blood glucose level difference between prilosec and zantac . Patients using Byetta must learn what to do if blood sugar drops too low zoloft causing excessive sweating . Other side effects include vomiting, diarrhea, dizziness, jitters, headache, and indigestion michael soma . Byetta should not be given to people with kidney problems or serious digestive disease prozac vs cymbalta . 273
Conclusions
By now, we hope you appreciate the importance of controlling blood sugar asacol delayed release tablet . Diabetes is common (some diabetologists believe it will soon affect nearly half the population), and its complications are devastating pfizer class action involving zoloft . We have tried to give you a variety of strategies to prevent or control this disease viagra and generic . Remember, though, that whatever tactics you adopt, you must work in close collaboration with your health-care providers prednisone and tracleer .
Below you will find an overview of our recommendations in this chapter rechargable aa lithium ion .
• Preventing diabetes is possible nolvadex steroids . Keep your weight under control, emphasize nonstarchy vegetables over pasta or bread, and avoid soft drinks, fruit juice, and processed meats you made everything possible again viagra .
• Get plenty of exercise, preferably including some time outdoors so you have 10 to 15 minutes of sunshine on your face and hands several days a week celexa proper dosage . If you don’t get outside, take 800 to 1,200 IU of vitamin D3 daily quetiapine and sustained release and dissolution .
• If you are diagnosed with diabetes, learn to monitor your blood sugar can toprol cause chronic abdominal distress . Keep track of how exercise and food affect it prozac and nerve receptors . Consider cinnamon or vinegar to help smooth out blood sugar in reaction to a carbohydrate meal nexium and indications .
• If you’re considering using herbs or dietary supplements such as chromium, bitter melon, fenugreek, Gymnema sylvestre, or nopal, check with your health-care providers before taking them zofran wafer . Monitor your blood sugar carefully ultram nopain .
• If medication becomes necessary, make sure that you and your physician find the safest and most effective option for you viagra nils . You shouldn’t have to suffer with dreadful side effects to keep your blood sugar under control iv ampicillin .

A-Z Principal Drugs (lithium succinate - menthol)

Saturday, June 27th, 2009

lithium succinate Lithium succinate appears to have sonic antifungal and anti-inflammatory properties, and is used as an 8% ointment for seborrhoeic dermatitis. (Ftalith).
lodoxamide A mast cell stabilizer similar to sodium cromoglycate. Used as eye drops (0.1%) in allergic conjunctivitis. (Alomide).
Dose: in acute diarrhoea, 4 mg initially, followed by 2 nig as required, up to a maximum of 16 ing daily. In chronic diarrhoea, 4-8 nig daily, but care is necessary in the elderly to avoid faecal impaction. Loperamide is not suitable for children under 4 years of age, nor in patients with liver disease, as it may cause undesirable sedation. (Iniodium).
loprazolam A benzodiazepine hypnotic used mainly in the short-term treatment of insomnia and nocturnal arousal. Dose: 1-2 nig at bedtime. Side-effects include drowsiness, dizziness, dry mouth and headache. See page 152 and Table 22.
loratadine An antihistamine with the general action of that group of drugs, but with reduced sedative side-effects.
Dose: 10 nig dailv. (Clarityn). See page I 10 and Table 2.
63
lofepramine An antidepressant of the irnipramine group, with similar actions and uses, but reduced sedative and anticholinergic side-effects.
Dose: 140-210 nig daily. (Gamanil). See page 128 and Table 11.
lofexidine A narcotic antagonist. It has a selective blocking action on brain nor-adrenaline, and is used for the rapid relief of opioid withdrawal symptoms associated with central sympathetic activity.
Dose: 200 pg twice a day, slowly increased as required over 7-10 days, before withdrawal over 2-4 days. Care is necessary in cardiac insufficiency and bradycardia. (Britl.olex).
lomotil A preparation of diphenoxylate with atropine, for the rapid control of diarrhoea. Dose: 2 tablets 6-hourly.
lomustine A slow-acting cytotoxic agent used in Hodgkin’s disease and solid tumours.
Dose: 130 ing/ni’body surface at intervals of (> 8 weeks. Side-effects, include anorexia. nausea, liver damage and niyelodeprm ion. Dosage should not be repeated until white cell and platelet counts have returned to an acceptable level. Reduced doses are given
when lomustine forms part of a multi-drug dosage scheme. (CCNU). See page 122 and Table 8.
loperamide A synthetic inhibitor of peristalsis.
lorazepam A short-acting anxiolytic/ hypnotic similar to diazepam, but less likely to cause next-day drowsiness. Dose: 1-4 mgdaily. It is also given in similar oral closes or by slow i.v. injection in doses of 50 pglkg for preoperative sedation and anuiesia. Occasionally used i.v. in status epilepticus in doses of 4 nig, but apnoea and hypotension are side-effects that may require resuscitation. fAtivan). See page 152 and Table 22.
lormetazepam A short-acting benzodiazepine hypnotic. It is useful in the treatment of insomnia in the elderly, but is less suitable for insomnia associated with early awakening.
Dose: 500 fig I nig at night. See page 152 and ‘]’able 22.
losartanV An angiotensin 11 receptor antagonist used in the treatment of hypertension.
Dose: 50ing daily The use of potassium-sparing diuretics should be avoided with losartan. It has the advantage of not causing the persistent dry cough associated with ACE inhibitors. (Cozaar). See page 148 and Table 21.
low molecular weight heparins See heparin.
loxapine Antipsychotic agent with the actions and uses of chlorpromazine. Dose: in acute and chronic psychoses, 25-50 mg daily, slowly increased as required. Maintenance doses range from 20-100111g daily. Side-effects are those of other anti-psychotic agents. but loxapine may cause nausea, vomiting and weight changes. f .oxapac). See page 168 and Table 30.
I Mob
magnesium hydroxide A mild antacid laxative, usually given in aqueous suspension as Cream of Magnesia, although tablet forms are also available. Cream of Magnesia is a useful antidote in mineral acid poisoning.
64
Lugol’s solution An aqueous solution of iodine 5% and potassium iodide 10%. Used in the preoperative treatment of t hyrotoxicosis.
Dose: 0.3-1 ml.
lymecycline A soluble complex of tetracycline and lysine. It has the action and uses and side-effects of tetracycline, but is absorbed more readily.
Dose: 800 mg daily. (Tetralysal).
typressin An analogue of vasopressin used to control the polyuria of pituitary diabetes insipidus.
Dose: 2.5-10 units several times a day by nasal spray. Side-effects include nausea and abdominal pain. I.ypressin has some vasoconstrictor properties, and desmopressin is sometimes prellcrred. (Syntopressin).
lysuride (lisuride) A bromocriptine-like drug for the treatment of parkinsonism. II acts by stimulating any surviving dopamine receptors in the brain.
Dose: 200 pg at night with food,
irk ceased at weekly intervals according to response up to a maximum of 5 mg daily. Side-effects include nausea, dizziness and initial hypotensive reactions which may affect driving ability. (Revanil). See
page 160 and Table 26.
magnesium sulphate Epsom salts. A powerful saline aperient, producing loose stools by preventing the reabsorption of water.
Dose: 5- 15 g before breakfast. Used externally for the treatment of boils and carbuncles as a paste with glycerin. A marked loss of plasma magnesium may occur after severe diarrhoea or drug-induced diuresis, and may require the i.v. infection of magnesium sulphate in doses based on the degree of hypoinagnesacmia. It has also been given i.v. in a dose of 8 mmol in the emergency treatment of severe;U’rhythinias associated with hypokalaemia.
magnesium trisilicate A white insoluble powder, with mild but prolonged antacid effects. It was formerly widely used in the symptomatic treatment of peptic ulcer;
now used chiefly for dyspepsia.
Dose: 0.3-2 g.
malathion An organophosphorus insecticide. Used as a lotion 0.5% for lice and scabies as alternative to lindane or carbaryl.
mannitol A sugar that is not metabolized, and is used mainly as an osmotic diuretic. Dose: (after a test dose of 200 mg/kg) 50-200 g by slow i.v. infusion over 24 hours. Mannitol has also been used by i.v. infusion as a short-term ocular hypotensive agent in the treatment of glaucoma. It is also useful in cerebral oedema, given by rapid i.v. injection in a dose of I g/kg as a 2044, solution.
macrolides A group of antibiotics that differ chemically from the penicillins, yet have a similar pattern of activity. They are active orally and are useful in the treatment of penicillin-sensitive patients. Erythromycin is the most widely used member of the group, with clarithromycin and azithromycin as more recent introductions.
magnesium carbonate A white, insoluble powder with antacid and laxative properties.
Dose: 0J-4 g daily.
maprotiline A sedative antidepressant with a general action similar to that of the tricyclic drugs represented by amitriptyline. Dose: 25-150 mg daily. If given at night as a single dose, the sedative action may reduce the need for other drugs. It has milder anticholinergic side-effects than some related compounds, although skin rash is more common. (I udionlil). See page 128 and Table 11.
mebendazole An anthelmintic effective against most intestinal worms.

Dose: 100 mg once for threadworm, and 100 mg twice daily for 2 days against other infestations. Generally well tolerated, but it should not be given to children under 2 years of age. (Verniox).
I Men
in oedematous states. A potassium supplement may be required. Care is necessary in renal and hepatic deficiency.
(KiYcaron). See page 148 and Table 21.
mebeverine An antispasmodic agent which, unlike the anticholinergic drugs, appears to have a direct action on the intestinal smooth muscle. It is useful in the treatment of gastrointestinal spasm and in the irritable bowel syndrome. Dose: .100 mg daily, before food. As with other antispasmodics, mebeverine should not be used in paralytic ileus. (Colofac).
medroxyprogesterone A synthetic progestogen.
Dose: in endometriosis 30 mg daily for 90 days; in dysfunctional uterine bleeding and secondary amenorrhoea: 2.3-10 mg daily for 5-10 days, starling on l6th-2 Ist day of cycle and repeated for 2-3 cycles. Large doses of 400 mg-1.5 g daily are given in breast, endometrial, prostate and other hormone-dependent cancers, or 250mg– I g weekly by deep i.m. inJection. (Farlutal; proves). Depot-proves is a long-acting product used by i.m. injection is a contraceptive. but only after fit][ counselling.
megestrol An orally active progestogen. It is used in oestrogen-dependent breast cancer, and acts by suppressing the uptake of oestrogens by the cancer cells.
Dose: 160 mg daily. Nausea and fluid retention with weight gain are occasional side-effects. (Megace). See page 122.
meloxicarn A recently introduced non-steroidal anti-inflammatory drug (NSAID) indicated in the short-term treatment of acute osteo-arthritis and the longer-term treatment of rheumatoid conditions. Dose: 7.5-15 mg once daily with food; half doses for the elderly. Suppositories of 15 mg are also available. The side-effects are basically those of the NSAI Ds in general. Meloxicam has a more selective action on cyclo-oxygenase, the enzyme involved in the biosynthesis of prostaglandins, and is less likely to cause gastrointestinal disturbance, but it has no cytoprotective action, and is not suitable for patients with peptic ulcer. (Niobic). See page 165 and Table 29.
65
mefenamic acid A non-steroidal anti-inflammatory analgesic agent used to relieve moderate pain in arthritic and rheumatoid conditions, and other states requiring mild analgesic therapy such as dysmenorrhoea. Dose: 1.5 g daily after food. Side-effects are drowsiness an(] haemolytic anaemia. Diarrhoea is an indication that the drug should be withdrawn. (Ponstan). See page 165 and Table 29.
rnefloquine A drug for the prophylaxis and treatment ofchloroquine-resistant malaria. Dose: lot- short -term prophylaxis 250 mg weekly, starting 1 week before exposure and for 4 weeks after return. Doses for treatment require specialist advice. Side-effects include gastrointestinal disturbances, dizziness and weakness. It is contraindicated in patients with a history of neu ro- psych iatric disturbance, and is not suitable for use in severe renal or hepatic impairment. (Lirium). See halofantrine.
mefruside A diuretic useful in the treatment of hypertension and oedema. Dose: 25-50 mg daily in the morning, according to need and response; 25-100 mg
melphalan An alkylating agent of the mustine type. Used mainly in myelomas, lymphomas and some solid tumours. Dose: 150-300 gg/kg daily for 4-6 days, repeated after 1-2 months. In myeloma it is also given by regional perfusion. The injection solution is highly irritant and contact should be avoided. Side-effects include myelo-depression, nausea, rash and pruritus. (Alkeran). See page 122 and ‘rabic 8.
menadiol A water-soluble form of vitamin K. Dose: 10 ing daily. (Synkavit) Phytorneii,dionc i.% now preferred.
menotrophin Human menopausal gonadotrophin containing follicle-stimulating hormone and luteinizing hormone. It is used in the treatment of anovulatory sterility. The dose depends on individual hormone assays and response. The use of the drug has resulted in multiple births. It is also given to males to stimulate spermatogenesis. (Humegon; Normegon).
menthol Colourless crystals obtained from oil of peppermint. Used as spray or drops for nasopharyngeal inflammation.

A-Z Principal Drugs (antidepressants - astemizole)

Tuesday, June 23rd, 2009

A-Z Principal Drugs (antidepressants - astemizole)
antidepressants The drugs used in the treatment of depression fall into two main groups, the so-called tricyclic antidepressants and the monoamine oxidase inhibitors (MA01s). (Unrelated drugs include lithium carbonate, used only for the prophylaxis and treatment of manic depressive illness.) The tricyclic group, which also includes sonic other compounds with a similar action, appear to act by blocking the neuronal uptake of central transmitters such as noradrenaline and serotonin. They are more widely used than the MAOIs because they are more generally effective, and interact less extensively with other drugs and certain foods. The tricyclic drugs are widely used in endogenous depression, particularly when sleep disturbances are present, but the onset of action is slow, and improvement may not commence until after 2-4 weeks of treatment. Extended therapy is usually required to avoid the risk of a relapse, and patients should be advised accordingly. Sonic tricyclic antidepressants, such as amitriptyline, have a sedative action of value when anxiety is a complicating factor, whereas a less sedating drug such as imipramine may be useful in patients exhibiting apathy and withdrawal. Some of the side-effects, such as dryness of the mouth, are linked with their anti-
cholinergic activity, but tolerance may develop with continued treatment. They also influence the cardio-vascular system and may cause arrhythmias, tachycardia and hypotension, and may interfere with the action of some antihypertensive drugs, although the response to beta-blocking agents is unaffected. Care is necessary in cardiac disease, and with the elderly initial doses should be low. The use of tricyclic antidepressants in epileptic patients may result in a lowering of the convulsive threshold. See page 128 and Table 11.
antidiabetic agents Diabetes mellitus is a deficiency disease due to a lack of insulin, and is characterized by an excessive level of glucose in the blood and urine. Treatment is either replacement therapy with daily injection of insulin, or orally by hypoglycaemic agents such as chlorpropamide. Such agents act by stimulating insulin secretion and release by the beta-cells of the pancreas, and are ineffective in the absence of such cells. See page 132 and Tables 12 & 13.
anti-D(Rh.) immunoglobulin An ininiurioglobulin that is given to a rhesus-negative mother to prevent her forming anti-bodies against fetal rhesus-positive cells which may pass into the maternal circulation during childbirth or abortion and which, in a later pregnancy, could cause haemolytic disease.
Dose: 504) units Lin. within 60-72 hours of delivery or abortion. Doses of 1250 units are given prophylactically. It is of no value it’given after anti-D antibodies have been formed. The inimunoglobulin has also been given after the transfusion of rhesus-incompatible blood. (Partobulin).
antiemetics Nausea and vomiting may be due to several causes, including stimulation of the chemoreceptor trigger zone in the reticular formation of the brain. Man), antiemetics have some degree of central activity, and in some cases their action may be mediated by blocking the effects of dopamine on the trigger zone. Effective drugs include some antihistamines and sonic phenothiazine-based tranquillizers such as prochlorperazine. The alkaloid hyoscine is widely used in travel sickness. More powerful drugs such as domperidone, metoclopramide, nabilone and ondansetron, are of value in the control of the severe nausea and vomiting induced by cytotoxic drugs. The use of antiemetics in early pregnancy requires great care, and is seldom essential.
antiepileptics See anticonvulsants, page 136 and’] able 15.
antihistamines Drugs such as promethazine are of value in conditions associated with the release of histamine from mast cells, such as hayfever, rhinitis, urticaria, pruritus, insect bites and stings. They are also useful in drug allergies. Some antihistamines also have antienietic properties, and are useful in travel sickness. Although all antihistamines have the same basic action, the degree and duration of response and the severity of side-effects may vary. Some antihistamines pass easily into the central nervous system arid are more likely to cause drowsiness. Others may have reduced anticholinergic properties, and cause less dryness of the mouth and blurring of vision. Care is necessary in epilepsy, glaucoma, hepatic disease or prostatic enlargement. See page 110 and Table 2.

antihypertensive agents See page 148 and Table 2 1.
anti-inflammatory agents See non-steroidal anti-inflammatory drugs (NSAIDS) and page 165 and Table 29.
antimetabolites Cytotoxic drugs that appear to act by combining irreversibly with cell enzymes, and so prevent cell division. Methotrexate and mercaptopurine are examples. See page 122 and Table 8.
dermatology and pruritus as oily calamine lotion. Arachis oil enema is used to soften impacted faeces.
argipressin A synthetic form of vasopressin.
artificial tears Some chronic sore eye con clitions may occur in rheumatoid arthritis, and may be due to tear deficiency. Solutions of itypromellose or polyvinylalcohol, sometimes referred to as’artificial tears’, are useful as a bland lubricant to replace the tear deficiency. (Isopto; Hypotears).
antimuscarinic agents See anticholinergic agent” page 160 and Table 26.
antineoplastic agents Anti-cancer drugs. See page 122 and ‘rabic 8.
antipsychotic agents See pages 117 & 1(,8, and Tables 5 & 30.
antitetanus immunoglobulin aulloglobulin obtained from plasma is used in injured patients who have not previously been immunized, and when tetanus is a definite risk. Dose: 250 units jan. A course of tetanus vaccine should also be commenced,
antitubercular agents See rifampicin, page 170 and I able 31.
antiviral agents See page 144 and Table 19.
anxiolytics See page H 7 and Table 5.
apomorphine A morphine derivative formerly used as a powerful emetic, but now considered to be too toxic. Occasionally used in the hospital treatment of parkinsonism. (Britaject).
apraclorildine
A clonidine derivative used as eye drops I 9A, to control intraocular
pressure during ophthalmic surgery. Some absorption may occur, so care is necessary in severe cardiovascular disease. (lopidine).
aprotinin An inhibitor of the proteolytic enzyme plasmin, obtained from bovine lung tissue. It is used in the severe haemorrhage due to hyperplasminaemia.
Dose: 500 000-1 000 000 units by i.v. infu.ioll. (Trasylol).
arachis oil Groundnut or peanut oil. It has
emollient properties, and is used in
ascorbic acid (vitamin C) Present in many citrus fruits. Deficiency is not uncommon in the elderly receiving inadequate diets. Severe deficiency causes scurvy, once the bane of seafarers.
Dose: for prophylaxis 25-75 mg daily; therapeutic dose 200-500 mg daily. Doses of 4 g daily are given for acidification of the urine. Claims that vitamin C prevents colds are unproven.
asparaginase Crisantaspase. See page 122 and Table 8.
aspirin (acetylsalicylic acid) Widely used as a mild analgesic and anti-inflammatory agent, often in association with other drugs such as paracetamol and codeine. Dose: 1.2-4 g daily, but in acute rheumatoid conditions doses of 4-8 g daily have been given. Long-term treatment with (loses of 75 mg daily are given liar the prophylaxis of cardiovascular disease. Side-effects include gastric irritation with some blood loss, hyperventilation, and bonitos, with the risk of deafness, may occur with high doses. Aspirin may cause rash and bronchospasm in asthmatic and other sensitive patients. As aspirin is now thought to be associated with Reye’s syndrome, the drug should not be given to children under 12 years of age unless specifically indicated. Aspirin may increase the effects of certain hypoglycaemic and anticoagulant drugs.
astemizole An antihistamine with an extended action and reduced sedative effects.
Dose: Wring once daily before food, and must not be exceeded. Higher doses may cause cardiotoxic side-effects such as ventricular tachycardia. Arrhythmias may follow combined treatment with many other drugs. (Hismanol; Pollen-ese). See page 110 and Table 2.

Herbal Remedies for Allergy Treatment

Tuesday, May 26th, 2009

Plants make a great many different chemical substances, mostly for the purposes of dissuading other living beings — fungi, insects and grazing animals — from consuming their

leaves, roots and fruits. These chemical substances are extraordinarily potent and diverse. Many taste disgusting, some are virulent poisons, and many will induce vomiting or

diarrhoea. None of these effects are surprising, given that substances such as these are produced to defend the plant. However, some of the chemical substances produced by

plants happen to have a beneficial drug-like action for people suffering from certain diseases. The effects of these substances are utilised in herbalism, sometimes known as

botanical medicine.
Over the millennia, herbalists have, through trial and error, tried to discover which plants have worthwhile effects. Indeed, this process probably began with our ape ancestors

– chimpanzees have been observed, when they are ill with parasitic infections, for example, to carefully select and eat particular leaves that have therapeutic effects. If

chimpanzees do this, it is a fair guess that the ape-like ancestors of human beings also did so.
At some point in human history – or prehistory – this use of wild plants became a systematic and specialised activity, now known as herbalism. No doubt the patients who went to

see herbalists (like patients visiting their doctors today) expected a cure for every ill, and no doubt herbalists felt bad about telling anyone that the problem was incurable.

At this point, quite a bit of wishful thinking and placebo effect (see p. 233) probably found its way into herbalism. The outcome was a mixed bag of herbal remedies – some that

worked, some that had no effect at all (apart from placebo effect), and a few that were positively toxic but whose bad effects escaped notice because of the seriousness of the

diseases being treated.
In recent times, a few herbal remedies have been put through rigorous scientific tests. As one might expect, some work and some don’t. More details of those that have been shown

to work
for allergies are given on p. 221. First, however, it is important to consider some of the misconceptions that surround herbal medicine, especially those relating to side

effects. These misconceptions are rooted in the basic philosophy of herbalism, so it is also important to look at this – and at other points of view about herbal treatment.
The ‘Mother Nature’ viewpoint
Some modern herbalists maintain that, for every human ill, nature has created a complete cure somewhere in the plant world – the job of herbalists is simply to identify that

cure. This belief is essentially religious and anthropocentric – that is, it assumes that the welfare of human beings is the central focus of the plant world. This goes against

common sense, because it suggests that plants produce a complex array of chemical components, not for their own benefit, but for ours.
A related idea, and one that is far more widely accepted, is that anything ‘natural’ must automatically be either harmless or positively beneficial to human beings. It’s a nice

idea, but nothing could be farther from the truth, as a quick survey of the plant world shows: hemlock is natural, belladonna is natural, and ricin –the most deadly poison known

– is natural. All come from plants.
Belladonna, of course, while being deadly poisonous in sufficient quantities, is also a medicinal plant. Its most significant ingredient, atropine, is a useful drug-like

substance in small amounts, and a poison in larger amounts. There is no sharp dividing line between these positive and negative aspects – even a small beneficial dose will have

some undesirable effects too.
In other words, herbs produce side effects, in just the same way that medicinal drugs do. This is almost inevitable – anything that alters body functions enough to act as a drug

will usually have some other unwanted effects.
In the case of herbal medicines, there is an added complication. Plants contain dozens, even hundreds, of different chemical substances, many of which have no benefits for

humans at all –they are just plain toxic. These plant toxins can produce various unpleasant effects of their own, to add to the side effects of the useful ingredients. So the

possibility of side effects is actually higher with herbal medicines than with medicinal drugs.
The side effects that occur with herbal treatment are sometimes very serious. Deaths have occurred in some cases, and in others, irreversible damage (e.g. to the liver) has been

done.
The ‘pure-is-best’ viewpoint
Many modern anti-allergy drugs were first obtained from plants –cromoglycate (see p. 148), for example, was originally extracted from the roots of an Egyptian plant called

ammivisnaga. The ground-up roots of this plant contain a great many other things besides cromoglycate, whereas the pharmaceutical preparations of cromoglycate are pure and of

known strength. This pure form of the drug has also been tested very thoroughly by pharmaceutical companies, in order to demonstrate its effectiveness, to identify the correct

dose, and to look for any serious side effects.
An advocate of scientific pharmacology would maintain that, with modern drugs, the patient is just taking the substance that works, not a mysterious cocktail of unknown plant

chemicals. In other words, you know what you are getting with a drug. You also know it has a good chance of working, and a relatively small chance of causing serious side

effects. With a herbal remedy, you are, to some extent, taking a leap in the dark.
Ephedra sinica, the herb known to the Chinese as Ma-huang, illustrates this point well. It contains a mixture of substances, including the powerful drug called ephedrine – it

was named after the plant. Ephedrine (see p. 156) can relieve the narrowing of the airways that occurs during an asthma attack. The presence of ephedrine gives Ma-huang the

ability to ease asthma, although it is more often recommended to help with weight loss. Unfortunately, over-use of Ma-huang can cause a spasmodic
contraction of the blood vessels in the brain, which can result in injury or death. Liver toxicity has also been recorded (see p. 220).
As for its anti-asthma ingredient, ephedrine, although this drug was once important in conventional asthma treatment, it is rarely prescribed now. Ephedrine has long been

superseded by other asthma-relievers that have a more precise effect on the airway muscles, and so produce fewer side effects.
The multiple-action viewpoint
Practitioners of Chinese herbal medicine, in preparing a treatment for atopic eczema, combine ten or more different herbs. There are some conditions, they say, that can be

treated with a single plant, but atopic eczema is not one of those. It requires a mixture – and none of the ingredients of that mixture, taken alone, has any effect. What they

are claiming is that the different drug-like substances in the herb mixture have a synergistic action, working together to treat the disease.
This same idea is sometimes applied to the many different chemical substances found in a single plant. Some herbalists argue that a herbal remedy is better than a modern drug

precisely because it contains a cocktail of different drug-like substances, the effect of one augmenting or balancing that of another.
There is no actual evidence to support this claim, but the fact that Chinese herbal mixtures have some success in treating difficult allergic diseases (see p. 221) demands that

Western doctors at least take the possibility of synergistic action seriously.
It might seem that this multiple-action viewpoint goes against the whole grain of Western scientific pharmacology – the ‘pure-isbest’ approach. However, Western medicine

frequently treats certain allergic diseases, such as asthma and chronic sinusitis, with a mixture of drugs.
Using herbal remedies safely
Always talk to your doctor before taking any herbal medicine, because of the risk of side effects, or interactions with any conventional drugs that you may be using.
If possible, get herbal treatment from someone who is also a doctor qualified in conventional medicine. Ideally, your herbalist should have access to laboratory facilities and

should order blood tests to monitor your reaction to the herb(s). Monitoring every 1-3 months is necessary with some herbs, to check for serious side effects such as toxicity to

the kidneys or liver (see p. 220).
Before buying herbal remedies from a health-food shop or via the Internet, contact the manufacturer and ask to see detailed reports of trials showing that the product is safe.
Think very carefully before taking a herb that has not The Chinese approach
One fundamental concept of Chinese medicine is that, rather than just matching the remedy to the disease, the treatment should also be based on the particular characteristics of

the patient concerned. This idea is shared by some other Eastern systems, such as Ayurvedic medicine.
Whereas a Western doctor might see you as a person with atopic eczema, a traditional Chinese doctor sees you as a person with a certain constitution which has got out of balance

and so produced symptoms in the skin. The constitution is usually the main focus of treatment, not the eczema. This approach means that different eczema patients get different

herb mixtures, and the same is true for other allergic diseases.
A traditional Chinese doctor will assess your constitution by taking your pulses (there are several in Chinese medicine, not just one), asking various questions, and studying

the appearance of your tongue – the same sort of diagnostic process that is used prior to acupuncture.
For the purposes of scientific investigations, where a uniform treatment is necessary, this traditional approach has been modified. A single standardised treatment is applied to

a particular disease – and the disease itself is diagnosed by Western medical criteria. Whether this is really comparable with traditional Chinese herbal medicine is open to

question. The same caveat applies to any off-the-peg Chinese herbal formula that is sold direct to the public, rather than being prescribed for an individual patient by a

trained practitioner.
The traditional philosophy of Chinese medicine makes for a lot of variability in herbal preparations. That is why categorical statements about side effects cannot be made –

while one mixture used for atopic eczema may contain a potentially toxic ingredient, another mixture may not.
undergone full safety trials. Find out all you can about the herb and discuss the matter with your doctor. Don’t fall for the ‘it must be safe – people have been taking it for

centuries’ argument. If a herb is only toxic to a minority of people, and its bad effects are slow to emerge (so people don’t get ill or die immediately after taking it for the

first time), its deadliness can escape notice for a very long time, perhaps indefinitely. In the case of pharmaceutical drugs, highly sophisticated information-gathering systems

are needed to ensure that such rare-and-slow effects are noticed (see p. 137) but nothing of the kind exists for herbal medicines.
Above all, do not neglect vital medical treatment (e.g. inhaled steroids for asthma) while trying out herbal remedies, as this can be dangerous. Always follow your doctor’s

advice about your drug treatment.
Risks to the liver
Among the side effects recorded for herbal treatment, liver damage is especially alarming. Deaths from liver failure have occurred with both Western and Chinese herbal

treatment. Liver toxicity has been recorded with the following herbal remedies: kava-kava, chaparral, germander, skullcap, mistletoe, senna, valerian root, jin bu huan, and

ma-huang or ephedra (Ephedra sinica). Some Chinese herbal teas prescribed for atopic eczema may also affect the liver, but this is not true of all eczema preparations – several

of the most widely used ones appear to be relatively safe.
Any medicinal herb might, in certain people, harm the liver. Should you feel ill while taking a herbal remedy, stop taking it immediately and see your doctor. The early symptoms

of liver toxicity, which you should watch out for, include jaundice (yellow
skin, and a yellowish tint to the whites of the eyes), pale faeces, dark urine, nausea and pain (usually in the region of the stomach).
Illicit steroids
Be very cautious indeed about pots of Chinese herbal cream sold for atopic eczema. Analysis of a selection of such creams found that two-thirds illicitly contained powerful

steroids – the very drugs that the people buying the creams were anxious to avoid. The dose of steroid in these herbal creams was alarmingly high, considering the purposes for

which some of them had been prescribed – such as use on the face of a baby. A substantial risk of serious side effects exists with these adulterated creams.
Sensitivity reactions to herbs
Like other natural products, herbs can provoke a true allergic reaction, and anyone with a tendency to allergies is at particular risk. Although any herb could, in theory, cause

such a reaction, some seem especially likely to do so:
•    Echinacea, which sometimes causes anaphylaxis or an asthma attack. Severe reactions may occur even in people taking it for the first time, if they are already allergic

to other plants in the daisy family (such as ragweed or mugwort).
•    Preparations containing royal jelly (obtained from honeybees) have sometimes caused near-fatal anaphylaxis in those allergic to pollen. Propolis, obtained from bees,

should also be treated with caution.
Contact dermatitis often occurs with tea tree oil and some other plant-derived substances applied to the skin (see p. 55).Herb—drug interactions
Using herbal remedies and taking medicinal drugs at the same time can be hazardous. These are the herbs that interact with anti-allergy drugs:
•    aloe vera, buckthorn, cascara sagrada bark, ginseng, and senna pod or leaf can all interact with steroid tablets
•    squill, lily of the valley and pheasant’s eye can increase the action and side effects of betamethasone (a steroid); rhubarb root also interacts with this drug
•    kava-kava, if taken with cetirizine (an antihistamine) can increase side effects such as drowsiness and poor coordination; it may have the same effect with other

antihistamines.
Note that many drugs prescribed for conditions other than allergies may interact with herbs. Some of these interactions can be serious, so check with your doctor before taking

any herbal medicine.
Herbs that may work for allergies
Of the herbal treatments that have been tested, the following appear to have potential benefits for people with allergies:
•    Chinese herbal teas for atopic eczema have shown good effects in scientific trials in Britain with both adults and children. Patients with widespread and persistent

eczema —which is particularly difficult to treat — were chosen for these trials. The puzzling thing is that when exactly the same herbal treatment was studied in Hong Kong, with

Chinese youngsters suffering from eczema, there was no improvement.
A combination of Chinese herbal medicine and acupuncture shows some limited benefits for hayfever patients (see p. 215). Pilot studies also suggest that a Chinese herbal

medicine formula may work for asthma.
More surprisingly, another mixture of herbs shows promise in reducing sensitivity for people with severe food allergy (so that there is less risk of fatal anaphylaxis from

accidentally eating the culprit food). Further research is needed to confirm these results. It is hoped that daily treatment for about six weeks will give 6-12 months’

protection.
If you are interested in trying Chinese herbal medicine, it is advisable to be monitored properly, as liver toxicity has sometimes occurred (see p. 220). See a reputable,

medically qualified practitioner, who can vouch for the contents of the herbal mixtures (imported ready-made mixes sometimes contain drugs such as steroids). Be warned that the

stuff tastes vile, and you have the daily chore of boiling it up before taking it. It can have a very mild laxative effect at first. Don’t use Chinese herbal creams unless they

are guaranteed steroid-free (see p. 220).
•    Euphorbia acaulis has shown good effects with atopic eczema. Liquorice root may also help, but can have serious side effects if taken in large amounts.
•    Evening primrose oil taken in capsule form, is known to calm inflammation, and might be helpful for atopic eczema. Don’t chew the capsules, as irritation of the throat

can occur. Epileptics should not take this oil.
•    Ginkgo biloba seems to reduce the reaction to allergens. For those with asthma it may also calm inflammation in the airways.
•    Ayurvedic medicine utilises two herbs, Coleus forskohN and Tylophora asthmatics, in the treatment of asthma. The former relaxes the airway muscles, in much the same way

as beta-2 reliever drugs, making the airways open up. The latter has more general benefits in asthma, but also some unpleasant side effects: it can cause nausea and soreness in

the mouth.
•    Saiboku-to is a Japanese herbal treatment for asthma. Studies suggest that it may have beneficial effects on airway inflammation and may allow a reduction in the dose of

steroids needed.
•    Butterbur has received a lot of publicity following a study which appeared to show that it was as good as the antihistamine cetirizine for hayfever However, the study

did not assess actual symptoms of hayfever, only the patients’ sense of wellbeing. Some preparations of this drug contain substances that could cause cancer, or carry a risk of

liver toxicity. Trials of butterbur for atopic eczema have shown no benefits.
•    Perilla seed oil appears to damp down allergic responses, and may help some asthma sufferers.
Omega-3 oils
These oils are derived from certain types of fish. They are obviously not herbs, but they are often sold alongside herbal remedies in health-food shops, which is why they are

included here. Generally speaking, omega-3 oils have a calming effect on inflammation,
but occasionally they provoke skin rashes, and asthmatics who are sensitive to aspirin may find that they gradually get worse if they take omega-3 oils. This is probably due to

problems with the production of messenger chemicals called prostaglandins in people with aspirin sensitivity (see box on p. 151). The connection is that omega-3 oils can act as

raw materials for the manufacture of prostaglandins and leukotrienes. The details of how omega-3 oils cause trouble for aspirin-sensitive people are not yet understood.