Friday, August 7th, 2009
Over the last two decades, there has been a significant rise in the number of couples experiencing fertility problems:
• Sperm counts have dropped by 50 per cent in the last ten years.’
• Men are showing an increasing number of sperm abnormalities.
• A quarter of all couples planning a baby have trouble conceiving.
• It is not uncommon for a couple without any fertility problems to take two to three years to conceive.
• One in four women miscarry. Some experience repeated miscarriages – as often as ten times.
• More and more couples are turning to fertility treatments to enable them to have a family.
• Of the couples who seek medical help, 30 per cent are told they have ‘unexplained infertility’ for which the doctors can offer no treatment.
If you are reading this book, you or your partner may have experienced problems trying to have a baby. You may have gone through fertility treatments that failed. Or you may just be worried that nothing is happening. I see hundreds of couples every year who are trying to conceive and I fully understand their unhappiness and frustration at not being able to achieve something that most of us grew up believing would happen whenever we wanted.
But, as the above statistics reveal, you are not alone. There is an epidemic of infertility and subfertility – and in many cases the doctors do not know the answers.
But, before we discuss these issues, I want to say:
Don’t lose heart
I believe that getting yourself and your partner into optimum health, usin the four-month programme outlined in this book, will give you the best possible chance of having that longed-for, healthy baby.
I don’t just believe it — I know it. By the time you have finished readin), this book, I hope I will have inspired you and your partner to take contrd of your health and fertility.
Nature is wonderfully clever. At this particular moment you may not think so, because on the most fundamental level, reproduction, it seems to have let you down. But the purpose of this book is to encourage you to restore your own and your partner’s fertility to its proper ‘natural’ state by simple lifestyle and dietary changes that eliminate toxins from your bod i and ensure that you have the level of nutrients needed for conception.
Fundamentals of Health
In the animal world, fertility is paramount for the survival of any specie However, the human race today has a number of fertility problems. Men are showing sperm abnormalities (such as sperm with two heads or sperm tha-:
are so sluggish they cannot reach the egg). Some women have a number Or menstrual cycles during which they do not ovulate; or, when fertilisation happens, the embryo does not implant in the womb.
To explain these anomalies, we have to go back to the foundations 0: health.The egg and sperm are only as healthy as the man and woman who produce them. If there are any problems with either the egg or the sperm. however subtle, nature will either try to stop fertilisation occurring or, if i does take place, a miscarriage may follow.
One reason why so many couples are diagnosed with ‘unexplained infer - tility’ is that doctors cannot put it down to a specific, observable medical cause. But I believe that infertility is a multi-factorial problem and should be investigated that way. That means looking at a variety of issues, such a, nutrition, alcohol and smoking habits, levels of lead and other toxic metals pesticides, food additives, genito-urinary infections, allergies, stress and other hazards of modern life.That means your partner taking a close look a: his health and nutrition as well (in four out of ten cases of infertility, the problems are on the male side). The fact is that our modern ‘unnatural lifestyle, combined with the nutrient depletion of much of our food, ha;
left many of us deficient in the vitamins and minerals we need for successful babymaking.
Any specialist who works in a zoo, or breeds champion dogs, cattle or racehorses, will tell you that optimum nutrition is essential. But, while the fertility clinic business is booming (with desperate couples lining up for treatment), there isn’t much incentive to look at whether simple factors, like a deficiency of zinc for instance, may be the main reason for unexplained infertility.
Learning From the Past
We should learn from the folic acid story, which really demonstrates the importance of nutrition and how a crucial deficiency identified by researchers as being responsible for birth abnormalities was ignored by doctors for years.
In 1991 the Medical Research Council (MRC) finally published a study which showed that supplementing with folic acid during preconception and pregnancy could prevent the reccurrence of spina bifida in babies.’ Yet the damaging effects of a folic acid deficiency had been recognised three decades earlier, after rats were born with malformations (including neural tube defects) and other problems (such as club foot and cleft palate) in folic acid trials.’
This knowledge, which could have prevented a great deal of heartache, had been around for over 30 years and yet women were not told to take folic acid for decades.These early findings were confirmed again in humans in 1981 trials that looked at the effects of folic acid on the prevention of spina bifida.’
Even as recently as 1993 the Daily Mail ran an article asking ‘Could this vitamin save your baby?” It said, `The fact that a supplement which can stop women having spina bifida babies remains the best kept secret of preconceptual care has now prompted sharp criticism from the medical world: ‘
Cynically, one might suppose that if folic acid had not been a simple easy-to-obtain supplement but a highly profitable pharmaceutical drug we would all have known about it years ago. You cannot patent a nutrient so there is no commercial incentive to investigate and promote it.
But the big lesson we should learn from the folic acid story is that our diet — what we eat or don’t eat — is absolutely crucial to our fertility.
How to Use This Book
Folic acid is only the tip of the iceberg. Medical and scientific literature contains a great deal of information that call help couples who are having difficulty conceiving or who have had previous problems such as miscarriages and malformations. This book presents that information in an easyto-understand form so that you call use it yourself. Having this knowledge will help you gain control of your own health and fertility.
By following the advice in this book you can increase your fertility anc reduce the possibility of miscarriage. liven if you have a condition like blocked fallopian tubes (which means that you need IVF treatment in order to have a chance of conceiving), this book will increase your chance of success. With assisted conception techniques it is still vital for the sperm anc the egg to be as healthy as possible.
As you read the recommendations, you’ll realise that the changes you make to increase your fertility are the same as those that will protect you from miscarriage and help you produce a healthy baby. They are also, quite simply, recommendations that will improve your general health. The advice
is so logical and makes such sense that you will probably wonder why nc one has told you all this before.
Finding that you can’t conceive when you want is a real shock and it is not something that many of us want to talk about even to our close friends and families. GPs and consultants are busy people and, all too often, overworked. The minute you come out of the consulting room you think of .1 dozen other things you wanted to discuss. There just isn’t time to talk in as much depth as you would like. Yet you want to find out as much as you can.This book is designed to answer your specific queries as well as present a comprehensive self-help programme that will give you and your partner the best chance of conceiving.
• Section 1 outlines the different aspects of your life and health that could be causing your and your partner’s problem. This will help you identify what may be going wrong.
• Section 2 explains how you can help improve your and your partner’s fertility, concentrating particularly on good nutrition and Supplementing your diet.This is one of the most crucial sections in the book because it could be the key to solving your infertility problem by making some simple changes that are entirely within your own control.
• Section 3 explains what tests are available to help you identify any medical cause of infertility. It is important that your partner understands that lie must also be involved in this process.
• Section 4 describes the different fertility treatments available in the UK and reveals some heartening evidence that you and your partner can dramatically improve your chances of having successful fertility treatment, if you should need it, by following the advice in this book.
• Section 5 discusses the problem of miscarriage in depth and shows how you can help yourself overcome it.
• Section 6 puts it all into practice – and shows you how to organise your self-help programme for those vital months of preparation.This is really the most essential part of the book.
• Section 7 tells you how to care for yourself in pregnancy so as to ensure that you Krill have a healthy baby.
I believe that any couple planning to have a baby would benefit from following the kind of recommendations outlined in this book – not just Couples who have had problems conceiving.
If all this sounds too hard to stick to, just think how important it is … We plan our holidays and we train for a career so why should we expect to just have babies without any proper planning or preparation.- This preconception care period of three or four months shapes your baby’s future, both physically and mentally, so it could be the most important bit of planning you ever do in your life. My aim is to help you and your partner to optimum health to give you both the best chance of having a healthy baby. As a bonus, following these recommendations will make you both feel better, fitter and more energetic.
Self-help Strategies
Most couples who seek fertility treatment find out a great deal about sophisticated medical technologies but very little about the relatively simple measures they themselves can take to improve their chances of conceiving. These highly effective self-help strategies include easily implemented dietary and lifestyle changes. Such measures cost little or nothing, their success has been scientifically documented, and yet most of these couples will not have been told about them.Why on earth is this–
The cynical answer is that infertility has become `big business’.As Professor Robert Winston points out in his book Making Babies, there are now at least 21 IVF units in London alone. And more and more units are opening because they are ‘highly profitable in the private sector’. Couples who desperately want to have a baby are very vulnerable. Even though some IVF units have extremely low success rates, such couples are still willing to gamble a great deal of time and money in order to try to conceive.
In contrast, there are no big financial gains to be made in helping couple to look at their lifestyle or to correct their vitamin and mineral deficiencies Yet this approach makes such sense, and has been shown to give an unprecedented success rate.
Over the last 20 years, Foresight has pioneered an approach to fertility that looks at the fundamentals of health, including lifestyle, diet, pollutants, infections and environmental and occupational hazards and gives an unprecedented 80 per cent success rate. Researchers from the University of Surrey followed the progress of 367 couples over a period of three years (1990-3). The women were aged between 22 and 45, and the men were aged 25 to 59. In all, 37 per cent of the couples had a history of infertility, and 38 per cent had experienced between one and five miscarriages (others had had other problems, including still births, malformations and low birth-weight babies).
Many of the couples were older, coming to the trial as a1ast resort’.They were all asked to eliminate smoking and alcohol, and to follow the recommendations outlined in this book (such as buying organic food, having infections checked and having mineral analysis). All the couples were given personal supplement programmes and were then re-tested to make sure their levels had returned to normal.
By the end of the three-year trial, 89 per cent (327 of the couples) had given birth. Out of those couples with a previous history of infertility, 81 per cent conceived and had babies. Out of those who had experienced a previous miscarriage, 83 per cent had a baby within the three years of the Study, without experiencing another miscarriage.
Of the 327 babies born to the couples in the study, no baby was born before 36 weeks and none was lighter than 51b 2oz (2.368kg).There were no miscarriages, perinatal deaths or malformations. The national average for miscarriages is one in four so one could at least have expected 80 miscarriages, but there were none. No baby was admitted to a special care baby unit.
A number of the couples had already tried IVF – sometimes two or three times – without success.Yet 65 per cent of this group conceived naturally on the Foresight programme without needing another IVF cycle.
These results are undeniably impressive and speak for themselves. Yet sceptics maintain that they are ‘too good to be true’.To date, the results have been published in the Journal of Nutritional and Environmental Medicine but not in a standard medical journal.’ This is because, in order to be accepted by a medical journal, there must be a control group.
Ina normal double-blind placebo controlled trial, to assess the efficacy of a headache remedy, for example, volunteers are randomly assigned to either a control group (placebo) or a treatment group (headache remedy). The volunteers don’t know if they are taking the placebo or the remedy, and nor does the scientist running the trial. All the volunteers in the treated group get the same dose of headache remedy.
However, in this study each person was given an individual supplement programme according to their needs. So they were all taking different dosages and supplements, depending on how deficient or toxic they were.
This is an important point because the double-blind placebo controlled trial is the ‘gold standard’ in medicine but it cannot take into account that we are all unique and that we may need different treatments to increase our fertility. And it is this ‘individually tailored’ approach which I believe is the key to finding a natural solution to infertility. The fact is that 37 per cent of the couples in this study had an established history of fertility problems and had undergone medical investigation. They did something different – changed their dietary habits and lifestyle – and then conceived. The information contained in this book explains in detail my enhanced version of this preconception programme.
It worked for them. It could work for you.
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Monday, July 20th, 2009
Vitamin D
If you can exercise outside and get at least 5 to 10 minutes of sunshine on your face and hands three or four times a week, you will be doing one more valuable thing to prevent diabetes canine inj dexamethasone . For those few minutes, don’t use sunscreen, because it can block the formation of the “sunshine vitamin,” vitamin D cyclosporine side effects thyroid .There is growing evidence that lack of this essential nutrient may predispose people to metabolic syndrome and diabetes paroxetine formula . 225 Low levels of vitamin D make it harder for the body to make or secrete insulin elavil and immodium .
Vitamin D deficiency is far more common than you would imagine ultram no prescription needed . Experts report that the majority of the elderly lack adequate amounts of vitamin D circulating in their bloodstream low maintainance prednisolone . 221 That might be understandable drug classification of sertraline . Older people might not drink much vitamin-D-fortified milk because of digestive issues fexofenadine hcl tabs allegra . They probably spend less time outside, especially in the winter, and when they do go out, they bundle up, exposing very little skin to sunlight mixing alleve and asprin . They may also be more care-
“Solid evidence exists that vitamin D deficiency is detrimental to beta cell function, leads to glucose intolerance in animal models and humans, and predisposes to type 2 diabetes finasteride or dutasteride for steroids . food supplement anhydrous caffeine powder . plavix verdict . meperdine phenergan . A major practical conclusion that can be drawn from the studies conducted on vitamin D and diabetes to date is that vitamin D deficiency is undesirable, not only for calcium and bone, but also for glucose metabolism how does caffeine effect plant growth .”227
—C atenolol diabetes brittian . Mathieu et al dreampharmaceuticals online generic ultram ., Diabetologia, July 2005
***** Vitamin D
The sunshine vitamin is the best deal in town because it is free arimidex vs clomiphene for pct . This nutrient is associated with a lower risk of osteoporosis, fractures, depression, cancer, arthritis, and diabetes adalat la . Five to 10 minutes of sun exposure on the hands, arms, and face every 2 or 3 days is about enough to do the job for most people caffeine or coffee and plant growth . 228
If oral supplements of vitamin D are necessary because sun exposure is not practical, we recommend anywhere from 800 to 1,200 IU per day zyrtec generic form . Do not overdose, though india generic topiramate 200mg prices . Keep total intake under 2,000 IU daily prilosec risk .
Cost: $0 if you get your vitamin D from sunshine; for supplements, you could spend less than $30 per year
ful about putting on sunscreen in the summer to prevent skin cancer plavix and platelets . This will block 95 to 98 percent of vitamin D formation in the skin liquid baclofen medtronics .
What is more surprising is that younger people may also be vitamin D deficient dissolving naproxen . Researchers recruited physicians, medical students, and hospital visitors at Boston University Medical Center and asked them to give blood during a vitamin D awareness program erythromycin antibiotic vomiting . The investigators discovered that “36 percent of young adults aged 18 to 29 years had vitamin D deficiency at the end of winter side effects of zyrtec-d .”229 While we cannot prove that a lack of this nutrient is contributing to the diabetes epidemic, we would be surprised if it weren’t part of the story different names for fluoxetine .
There is will still no proof that getting adequate amounts of vi- tamin D wiprevent diabetes isosorbide mononitrate nursing management . Nevertheless, we think making sure you get enough of it makes sense for lots of other reasons (osteoporosis, arthritis, and cancer prevention, to name just three) etoposide capsules stability . If you cannot go outside three or four times a week for some sun exposure, consider a supplement doxycycline pediatric dosing .
Breastfeeding Protects Mom
Nursing a baby at the breast used to be the normal way of feeding a child until she got big enough to chew and swallow solid food birth control levitra pill . That changed in the early 20th century, though, as canned milk and infant formula became readily available seroquel and urinary retention . Many new mothers were urged to use the “modern”technology of bottle-feeding does actos afect the heart . Today, breastfeeding is still less common than formula feeding, even though scientists have discovered that it is better for the baby in many subtle ways depression libido viagra . But the latest discovery,is that it is also better for the mother, especially if she is at risk of developing type 2 diabetes later in her life information on the medication omeprazole .
Investigators affiliated with Harvard studied two large groups of nurses (one cohort had more than 83,000 women in it; the other, 73,000) for more than a decade metformin actos januvia . The longer a woman breastfed her infant, the less likely she was to be diagnosed with diabetes later cheap imitrex free consultation . The benefit didn’t really kick in, though, until she had nursed her baby for at least 6 months with no formula feedings on the florr dj caffeine . 230 Women who breastfed exclusively for at least a year got the most benefit, a 44 percent drop in the risk for type 2 diabetes spotting right before period on clomid . Unfortunately, though, lactation did not protect women who had developed gestational diabetes—high blood sugar during pregnancy phenazopyridine side effects . These women need to be treated for diabetes during the pregnancy; though their blood sugar may return to normal after delivery, they are at higher risk of developing type 2 diabetes for the rest of their life allegra farm horse carrage service ct .
Type 2 Diabetes
If a doctor suspects that a patient has diabetes, she will probably order a blood test prevacid and raw onions . When fasting plasma glucose is 126 mg/dl or higher, the diagnosis is clear how long does clomid work . Another approach is to administer a 2-hour glucose tolerance test cream diflucan . In this test, a person’s fasting blood sugar is measured and then he or she is given a sugary drink with a standard dose of glucose neonate ampicillin dose . Blood sugar is then measured at intervals over the next 2 hours cephalexin cost . If it is 200 mg/dl or higher, the doctor will probably diagnose diabetes caffeine strength and conditioning journal .
Diabetes treatment is not a do-it-yourself project maxalt and effects on pregnancy . Because this condition is so serious, it absolutely requires a close working partnership between patient and physician greenstone ltd peapack nj azithromycin . But it is too important to leave entirely up to the doctor paroxetine and . For the best control, a person with diabetes should be monitoring blood sugar at home and striving to keep it as close to the target range as possible riva clindamycin . A daily glucose diary that can be shared with the doctor will help to optimize the treatment program viadrene or levitra .
Monitoring Blood Sugar
It is sometimes possible to overcome type 2 diabetes with exercise, diet, and weight loss effectiveness clomid . To follow your progress, it makes DRUGS THAT MAY RAISE BLOOD SUGAR 231,232
amiloride + hydrochlorothiazide (Moduretic)
amlodipine + atorvastatin (Caduet) amphotericin B (AmBisome) amprenavir (Agenerase) arsenic trioxide (Trisenox) asparaginase (Elspar)
atovaquone (Mepron)
basiliximab (Simulect)
benzthiazide (Exna)
betamethasone (Celestone) bicalutamide (Casodex) budesonide (Entocort)
bumetanide (Bumex)
busulfan (Busulfex IV)
celecoxib (Celebrex)
chlorthalidone (Clopres, Tenoretic, Thalitone)
ciprofloxacln (Cipro IV)
clozapine (Clozaril)
cyclosporine (Neoral)
dexamethasone (Decadron) diazoxide (Hyperstat IV) didanosine (Videx)
doxorubicin (Doxil Injection) emtricitabine + tenofovir (Truvada)
estradiol (Activella, Alora, Cenestin, Climara, Esclim, Estrace, Estraderm, Femhrt, Premarin, Prempro, Vivelle, etc buy now norvasc .)
fentanyl (Actiq)
fludarabine (Fludara injection) furosemide (Lasix)
gatifloxacin
gemtuzumab (Mylotarg injection) goserelin (Zoladex)
hydrochlorothiazide
hydrochlorothiazide + losartan (Hyzaar)
hydrochlorothiazide + moexipril (Uniretic)
hydrocortisone (Cortef) indapamide (Lozol)
interferon alpha-2b (Intron A) leflunomide (Arava)
leuprolide (Lupron Depot)
levalbuterol (Xopenex Inhalation Solution)
lovastatin + nicotinic acid (Advisor) megestrol (Megace)
metformin + rosiglitazone (Avandamet)
methylprednisolone (Medrol) mycophenolate (CellCept) mycophenolic acid (Myfortic) nicotinic acid (Niaspan)
nilufamide (Nilandron)
octreotide (Sandostatin)
ofloxacin (Floxin)
olanzapine (Zyprexa)
olmesartan (Benicar)
oral contraceptives with 35 micrograms ethinyl estradiol or more
(Brevicon, Demulen 1/35, Enpresse, Modicon, Mononessa,
Necon 1/35, Norinyl 1 +35, Nortrel 1/35, Ortho-Cyclen, OrthoNovum 1/35, OrthoTri-Cyclen, Ovcon 35, Sprintec,Tri-Levlen, Tri-Norinyl,Triphasil,Trivora, Zovia 1/35E, etc avandia glipizide .)
pegaspargase (Oncaspar) pentamidine
prednisolone
prednisone
ritodrine (Yutopar)
rituximab (Rituxin)
rosiglitazone (Avandia)
salmeterol (Serevent Diskus) saquinavir (Invirase)
sargramostim (Leukine)
sirolimus (Rapamune)
sotalol (Coreg)
tacrolimus (Prograf)
tenofovir (Viread)
terbutaline
testosterone (AndroGel) tiotropium (Spiriva HandiHaler) torsemide (Demadex)
triamcinalone
triamterene + hydrochlorothiazide (Dyazide, Maxzide) valganciclovir (Valcyte)
sense to get a home blood sugar monitor and learn to use it on a regular basis tramadol blood test intefere . Exactly what is regular will vary from one person to another and is something you and your doctor will need to work out kamagra oral jel . Some people have a lot of difficulty stabilizing their blood sugar and may need to measure it several times a day, both fasting and 1 to 2 hours after meals spironolactone for hormonal acne . Until blood glucose is brought under control, you should plan on measuring it at least twice a day and possibly more often vigora .’33 When blood sugar is consistently at target levels, you might do fine measuring blood glucose just a few times a week 150 cheap fluconazole generic mg .
There are many different blood sugar monitors on the market; you may want to check Consumer Reports fora recommendation celexa message boards toc . Whenever you measure your blood sugar, be sure to record the time of day and the circumstances as well as the value to help your doctor figure out the best treatment plan and evaluate any medications he may have prescribed drug generic form of finasteride .
will
Your physician also be taking regular blood tests to assess your glycosylated hemoglobin edinburgh viagra mmr find search . Having elevated levels of glucose in the blood eventually affects hemoglobin, an oxygen-carrying molecule concerta and prozac . The measure is called HbA, , and it offers a way to assess blood sugar control over several months benazepril side effects eye . This will give you and your doctor a way to tell how well your regimen is working to keep your blood glucose under control what company makes cialis . In people without diabetes, HbAl atarax sl80 . runs somewhere between 4 and 6 per- cent and varies slightly from lab to lab acomplia side affects . Your doctor will want you to try to keep your HbA,, under 7 percent zyrtec toddlers .’ Monitoring your blood sugar at home on a regular basis can help you in this endeavor, and might reduce your risk of serious complications like heart attack and stroke pepcid drugs .’-35
Diabetes Triggered by Drugs
When you are first diagnosed, you should discuss with your doctor whether your diabetes might have been triggered by a medicine you take buy imitrex tablets . In some cases, your physician may be able to prescribe a different medication and your blood sugar level may drop nizoral tinea versicolor . In other cases, there is no acceptable substitute for a lifesaving medication milk thistle coumadin . Treating the resultant diabetes could be considered a fair trade for being alive can you take valtrex while pregnant .
It is not always possible to predict whether a medication will cause hyperglycemia (high blood sugar) in a particular patient illinois ephedrine pseudoephedrine sales tracking log . People vary enormously in susceptibility to this effect; some people react strongly to a diuretic, for example, while many others are unaffected digoxin usual dosage . Although a very small proportion of women on oral contraceptives may experience this problem, so many women use them that it may add up to quite a few people lithium c500 .
The list on the preceding pages is not complete, but it offers a snapshot of some of the drugs for which this reaction has been reported snort ibuprofen mixed with acetaminophen . If you take one of them, do not stop the medication on your own periodic table of caffeine beverages . Discuss your concerns with your physi- cian cvs paxil . You may also discover, as some people have reported to us, that medications not on the list, such as the cholesterol-lowering drug Lipitor (atorvastatin) and some other statins, may occasionally raise blood sugar hydrochlorothiazide erection problems .
Diet Does Count
Your doctor will surely urge you to watch your diet lexapro comments . Here again, we suggest you check out Dr clomid iui tender nipples hot flashes . Richard K low dose naltrexone chron’s disease . Bernstein’s suggestions labetalol 100 mg iv . In addition to The Diabetes Diet, Dr amoxicillin 500mg side affects . Bernstein’s Diabetes Solution goes beyond diet to total diabetes management, and his suggestions are worth consideration amiodarone lawsuits . Our earlier recommendations on diet for preventing diabetes mostly hold for people who already have diabetes as well, with two big exceptions generic prozac for menopausal symptoms . Once a person has actually developed diabetes, chocolate and coffee may destabilize blood sugar too much in the short term and in many cases should be avoided avoiding caffeine .
Cinnamon
There are some other unexpected items you might want to include in your diet, though tramadol 120 ea cheap . One is cinnamon alternative strattera . Surprising as it seems, 1/4 to 1/2 teaspoon of cinnamon from the spice rack added to food or a beverage can help lower blood sugar if the rest of the diet is sensible gemfibrozil 600mg . Cinnamon appears to increase insulin sensitivity loratadine orally . 216 Giving a cinnamon extract to diabetic mice lowered blood sugar, raised HDL cholesterol, and reduced triglycerides soma 44 pics . 237
There are two types of cinnamon, and the benefit appears to be primarily from cassia cinnamon (Cinnamomum cas-
238
sia) royal jelly warfarin . Although this is the common cinnamon from the spice shelf, some grocery store cinnamon contains a compound called coumarin vliet estradiol day 21 . With regular use, coumarin could be toxic to the liver side effects of zoloft dopamine depletion . It may also interact with anticoagulants such as warfarin (Coumadin) can prednisone stop orgasm in women .
Cinnamon can help stabilize blood sugar, and may help control cholesterol and triglycerides antabuse no prescription . Effects are mild, so cinnamon should not be substituted for medical treatment imitrex weight .
Downside: Heartburn; possible liver damage from coumarin contamination
Cost: $30 to $40 a month for Cinnulin
People who use cinnamon regularly should be monitored for any potential toxicity lifetime synthroid therapy . Richard A aldactone sinus pressure . Anderson, PhD, one of the scientists doing research on cinnamon, says a water-based extract is effective and safer than plain cinnamon side effect gabapentin . People can take cinnamon capsules such as Cinnulin PF, or they can put cinnamon in a coffee filter and pour hot water over it to create their own water extract pamelor and dose .
The Value of Vinegar
Another dietary addition that is worth consideration is vinegar interactions levitra niacin . This old remedy has been floating around for decades, if not centuries syrup zantac gastroesophageal . But if you were to ask most registered dietitians whether vinegar is helpful for diabetics, you would probably get a blank stare lipitor plavix . Surprisingly, there is now good science to support the value of vinegar infrmation on tenoretic . Researchers in Sweden report that when vinegar is given with white bread, it reduces blood sugar and insulin levels lamictal and ovulation . 139 It also helps people feel fuller up to 2 hours later dosage prescription info for albuterol .
Japanese researchers have found that vinegar can counteract the effect of white rice on blood sugar cialis the dangers fda . 240 And investigators at Arizona State University report that 2 tablespoons of vinegar or a handful of peanuts before a starchy meal can significantly dampen the resulting rise in blood glucose morphine ami chf atenolol .241 Pickles may be the most palatable way to consume vinegar; drinking it, even mixed with water, may be difficult for some people prozac loss of sex drive .
I suffer with type 2 diabetes ritalin bupropion . My doctor prescribed Glucotrol for my blood sugar It helped to a degree, but I have found that by adding apple cider vinegar and cinnamon to a careful diet, I can control my blood sugar even better Oolong Tea
Consider sipping oolong tea with your meal what year was penicillin found . This type of tea is made from a partially fermented leaf, midway between green tea and black tea blood in urin caused by plavix . Research from Taiwan indicates that drinking oolong tea (1,500 milliliters per day, or around 6 cups) significantly lowered both blood glucose and fructosamine, a longer-term measure of blood sugar control bristol-myers squibb income lipitor .141 (Blood glucose measures sugar in the blood right now; fructosamine indicates how much sugar has been in the blood over the past 2 or 3 weeks; HbAl is a signal of blood sugar over the previous 6 weeks or more 2 weeks breast soreness clomid .) Oolong tea can be an acquired taste, but it’s definitely worth a try impact penicillin 20th century lives . It can’t hurt, and it might help what is after femara .
Herbs and Supplements
A huge array of botanical medicines and dietary supplements is offered to diabetics tramadol hydrochloride capsules 50g . Although several natural products can help control blood sugar, none is a substitute fora diet designed to keep blood sugar under control erythromycin 870 . If you decide to try an herb or supplement to help with-blood glucose control, be sure to inform your physician and get approval ultram bipolar . Monitor your blood sugar carefully and keep good records possible side effects from boniva . That way, you will be able to work with your doctor to adjust the dose of your medicine, if necessary, and you will be able to look back over your notes to evaluate if what you were taking lowered your HbAlc us prescription cialis . Because the quality of herbal products and dietary supplements varies widely in this country, keeping close track of how well you do may help you find a more effective or more consistent formulation soma water beds .
CHINESE HERBAL FORMULAS
There are a number of Chinese herbs that are traditionally prescribed in complex formulas allegra hives . Several herbs are included to help potentiate and balance the main ingredient or ingredients topamax used for pain . An objective analysis of available research evidence by the Cochrane Library found that several of these have been reported to lower blood sugar in controlled trials, but that the quality of the studies is fairly questionable overall 20mg lipitor qoclick .241 The reviewers suggest that herbal medicines such as holy basil or Bushen Jiangtang Tang merit further study 12v small lithium battery . We can’t disagree celexa increses anxiety . Any diabetic who chooses to try traditional Chinese herbs needs two doctors, though: one skilled in traditional Chinese medicine and the other up-to-date on endocrinology, espe-cially diabetes treatment medroxyprogesterone pregnancy test . It might be challenging to organize their close collaboration, but it is essential metformin and bowel movements .
BITTER MELON
Bitter melon, or Momordica charantia, is a plant in the cucumber/squash family that is used as a vegetable as well as a medicine in much of China phenytoin cognitive decline .” It does not increase insulin production, but it seems to improve sugar uptake by the cells trazadone used with cymbalta . Bitter melon has been reported to lower fasting blood sugar celecoxib content .245 It may be helpful not as a substitute for standard diabetes medicines, but in addition to them buy antabuse no prescription . Careful blood sugar monitoring is necessary tramadol from india pictures . Children and pregnant women should not take this herb, because it may be dangerous to them sun allergy and amoxicillin . Some children have died after eating the bright red seed coverings lexapro makes me drowsy .
A family friend told us that bitter melon could help reduce blood sugar We went to our local health food store and bought a bottle, and it seems to work! My husband takes metformin and glyburide for diabetes low levels of estradiol fsh hormones . After he added this supplement, his blood sugar level was down considerably wellbutrin xl and heart .
CHROMIUM
Chromium is an essential nutrient that is needed in minute quantities cialis lawyer columbus . It plays a role in glucose utilization and increases insulin sensitivity in tissue culture studies rayovac cr2020 lithium 3 volt . Chromium picolinate, which is often found in supplements, is relatively well
246
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Posted in Diabetes | No Comments »
Tuesday, May 19th, 2009
Drugs for Asthma
The drug treatment of asthma is far more complex than for any other allergic disease. Drugs prescribed for asthma fall into two basic categories: those that open up the airways by relaxing the airway muscles, called relievers, and those that treat the inflammation in the lining of the airways, called preventers. The former offer a ‘quick fix’ - like taking an aspirin when you have a headache. Just as the actual cause of the headache is not treated by an aspirin, so the actual cause of the asthma attack is not addressed by relievers. Preventers, on the other hand, tackle the basic problem - the inflammation that triggers the contraction of the airway muscles (see p. 36).
In the past ten years, there has been a quiet revolution in asthma treatment, with far more people being given preventer inhalers, usually low-dose steroids. The aim is to get the airways in better condition, with the inflammation thoroughly damped down, so that the airway muscles don’t go into spasm. The ultimate objective is to make people far less reliant on reliever inhalers, because the potential hazards of over-using them are now realised.
The details of modern asthma management, and the different approaches used, are described on p. 160, following the discussion of the main types of drug used for asthma treatment.
Beta-2 relievers (beta-agonists)
Our airways open up when we produce adrenaline. This is the body’s natural response to feeling angry or frightened. The adrenaline widens the airways so that we can run faster or fight more vigorously.
Adrenaline (epinephrine), given as a drug, was among the earliest treatments for asthma. However, it also stimulates the heart to beat faster and raises
the blood pressure. While it is useful for emergency treatment (see p. 155) the side effects make it too hazardous for routine use.
The beta-2 relievers work by mimicking adrenaline – they bind to the same receptors in the airways, the beta-2 receptors. Binding to these receptors stimulates the airway muscles to relax, so that the airways open up.
In other respects, the beta-2 relievers are not like adrenaline. Clever chemical manipulation has made them sufficiently different from adrenaline to have little effect on the heart and other organs, when taken at normal doses.
Beta-2 relievers are best taken by inhalation. Although tablets and syrup are available these are far more likely to bring on side effects, because the dose needed is so much bigger.
Inhaled beta-2 relievers target the drug directly on the airways, so the dose can be smaller. They also have the great advantage of taking effect soon after being inhaled, and giving full relief from airway narrowing within 10-15 minutes.
There are two different kinds of beta-2 relievers:
• the traditional short-acting beta-2 relievers whose effects last for 3-6 hours (usually about four). The modern consensus is that these should be used only when needed, not taken routinely.
• the newer long-acting beta-2 relievers, which last up to 12 hours. These drugs are prescribed for more severe forms of asthma (see p. 154), and are generally used routinely, twice a day.
A key question for asthma sufferers is: How often can short-acting beta-2 relievers be used? Ideas about this have changed considerably over the last 20 years, and no doctor would now want to have patients using a Ventolin inhaler five, six or more times a day - something that was quite common in the past. This level of need for beta-2 relievers indicates that the asthma is poorly controlled and requires treatment with a preventer, to quell the inflammation in the airways.
Detailed policy on beta-2 relievers still varies from one part of the world to another. British guidelines state that anyone who needs to use a short-acting beta-2 reliever more than once a day, or who suffers from nocturnal asthma, should be given a preventer as well. The international guideline is more stringent: if a short-acting beta-2 reliever is needed more than three times a week, a preventer should also be prescribed.
How safe are these drugs in the long term? The cause of the big re-think on beta-2 relievers was an epidemic of asthma-related deaths in New Zealand between 1976 and 1988. The death rate from severe asthma attacks was 2-4 times its previous level for a while, and over a thousand New Zealanders died in the epidemic.
There has been a huge controversy over what exactly caused these deaths. Most researchers now agree that the main cause was a new brand of inhaler that delivered a double dose of the drug fenoterol, a short-acting beta-2 reliever with a very powerful effect on the airways and quite high levels of side effects involving the heart. The same brand of inhaler may have been linked to increased death rates in Canada and Germany.
Research suggests that the problem was greatest in New Zealand because sales of the new inhaler were highest there, and because many patients got their inhalers through repeat prescriptions. As a result, people whose asthma was deteriorating badly were not seen by a doctor and were using large amounts of beta-2 reliever, rather than taking preventer drugs. This is now believed to be a major cause of asthma deaths. There are three separate factors involved:
• The beta-2 reliever covers up the effects of the severe inflammation of the airways. People feel reasonably well, because the reliever is opening up their airways, and don’t realise just how bad their asthma really is. The untreated inflammation in the airways can eventually lead to a very serious, and potentially fatal, asthma attack.
• The short-acting beta-2 reliever, used regularly, makes the airways more sensitive to exercise, and to allergens such as dust mite or pollen. This means that an asthmatic who is already allergic to these allergens reacts to them at much lower levels in the air.
• The airways become less and less responsive to the beta-2 reliever itself, so that when a serious attack occurs, requiring hospital treatment, huge doses of beta-2 reliever are needed to open up the airways. These massive doses carry a risk of serious side effects involving the heart.
The details of the New Zealand epidemic still evoke controversy. Was fenoterol itself, which is stronger than other beta-2 relievers, the cause of the deaths? Or was it just that the inhaler delivered a double dose - would any short-acting beta-2 reliever be dangerous at twice the normal dose? Or was it over-use of all beta-2 relievers and lack of preventer drugs?
Some common brand names
Common brand names include:
short-acting beta-2 relievers in inhalers - Aerolin, Airomir, Bricanyl, Ventolin short-acting beta-2 relievers in tablets - Bambec, Bricanyl, Volmax short-acting beta-2 relievers in syrup - Monovent, Ventolin
long-acting beta-2 relievers in inhalers - Bambec, Foradil, Oxis, Serevent
Until this is resolved, safety-conscious asthmatics may want to assume that any of these possibilities could be correct. An ultra-cautious approach would include:
• Avoiding fenoterol (it is no longer available in Britain, except in the Duovent inhaler, combined with an anti -choli nerg ic drug)
• Not using double-dose inhalers of any beta-2 reliever (i.e. inhalers that deliver 200mcg/ micrograms per puff)
• Not routinely taking two puffs of a single-dose inhaler (check with your doctor if you have been told to take two puffs)
• Using any short-acting beta-2 reliever only I as needed’ – which should be once a day or less according to British guidelines. Note that, with this level of use, there is absolutely no risk from these drugs: it is only regular over-use that is damaging and dangerous.
• Using a peak-flow meter and ensuring that you are assessed regularly by your doctor
• Always taking your preventer medication as prescribed.
Since about 1990, the death rate from asthma has been falling, particularly in countries with a policy of reducing use of beta-2 relievers, and increasing inhaled steroids. The death rate in New Zealand is now the lowest it has been for 50 years, and at the same level as in other Western countries.
Unnecessary alarm
While investigating the causes of the New Zealand epidemic, medical researchers discovered that patients inhaling a short-acting beta-2 reliever four times a day had more irritable airways after just two weeks. Their airways were also less responsive to the drug, even after this brief period of use.
Some researchers began to ask if the asthma epidemic itself – the increasing number of cases of asthma – could actually be due to these drugs. Maybe children with mild wheezing, which might have cleared up if left untreated (and which would have gone untreated in the past) were becoming full-blown asthmatics because they were now using beta-2 inhalers?
Many doctors became very concerned about these questions, and a leading medical journal
published an article with the provocative title: ‘Worldwide worsening wheezing – is the cure the cause?’ That was in 1992. Since then, much more research has been done, and it is clear that this particular fear about beta-2 relievers was unfounded.
Unfortunately, there are a few books and other publications around that are spreading unnecessary alarm about these drugs by reporting the debate as it was in 1992. They have taken up that question ‘Is the cure the cause?’, assumed that the answer is ‘yes’, and ignored all the subsequent research, which shows the opposite.
Beta-2 relievers in severe asthma
A few patients with severe asthma remain breathless and wheezy, even though they are inhaling moderate doses of a steroid preventer every day. Increasing the dose of inhaled steroids does not make a huge difference to their symptoms, and it substantially raises the risk of steroid side effects.
Taking a long-acting beta-2 reliever often works wonders for such patients. These relatively new drugs relax the airway muscles, and go on working for 12 hours or more.
There has obviously been concern about long-acting beta-2 relievers having the same sort of insidious side effects as their short-acting colleagues (see p. 153), and so increasing the likelihood of deaths from asthma. However, studies of people taking these drugs suggest that the risks are minimal. Certainly, long-acting drugs taken twice a day are very much safer than short-acting drugs taken four times a day.
Other studies show that the chemical differences of the long-acting drugs, as well as prolonging their effects, also give them a more complex set of actions in the body. For example, they improve the effect of steroids in calming inflammation, and may even have some small anti-inflammatory effect of their own.
Doctors believe that, for patients with troublesome asthma, the benefits of long-acting beta-2 relievers greatly outweigh the risks. But they should only be used in combination with inhaled steroids. Various other options, such as allergen avoidance and the new anti - leukotriene drugs (see p. 159), should probably be investigated as well.
If you are taking long-acting beta-2 relievers, do use them regularly, once every 12 hours – the good effect gradually builds up with consistent use.
Generally speaking, you should not take additional doses in between. These are not intended for use if you have a sudden asthma attack – your doctor will prescribe a short-acting beta-2 reliever for this. This limitation on the use of long-acting beta-2 relievers is certainly appropriate for salmeterol (which was the first of the long-acting beta-2 relievers to be developed) because it is very slow to take effect on the airways. However, one of the newer long-acting beta-2 relievers, called formoterol, begins to work just as quickly as a short-acting beta-2 reliever. Formoterol could, in theory, be used on an ‘as-needed’ basis to combat asthma attacks. You may want to discuss this possibility with your doctor.
Finally, don’t stop taking your preventer drug (e.g. inhaled steroid or cromoglycate), even if you feel a lot better. Long-acting beta-2 relievers are not a substitute for preventers.
Some patients with very severe asthma need to take regular doses of short-acting beta-2 relievers as well as long-acting beta-2 relievers. You should obviously follow the advice of your asthma specialist closely if you are on this kind of drug regime, and not change anything without approval. However, it might be worth discussing other options, such as anti -leukotriene drugs. In addition, do all you can to combat your asthma in other ways – by reducing allergen exposure, avoiding asthma triggers (see p. 39), and employing various other self-help measures (see p. 41).
Immediate side effects of beta-2 relievers
Minor immediate side effects of these drugs include:
• headache
• nervousness, trembling, restlessness, anxiety; children may become more excitable, and some are badly behaved or even aggressive.
• flushing
• dry mouth
• muscle cramps.
These side effects – all of which are due to the resemblance of beta-2 relievers to adrenaline – usually wear off relatively quickly. Some long-acting beta-2 relievers may cause nausea and vomiting.
A pounding heart is usually a relatively minor side effect, but it can be more serious, and should be reported to your doctor.
A few asthmatics find that their airways tighten up when these drugs are inhaled, rather than opening. This is called paradoxical bronchoconstriction. If this happens, stop using the inhaler and see your doctor as soon as you can.
Even more rarely, asthmatics can develop allergic reactions to the drugs, or suffer hallucinations or seizures. Obviously you should stop using the inhaler immediately if you experience side effects of this kind, and should see your doctor.
There can be an interaction between beta-2 relievers and other drugs or medical conditions. Should you need a diuretic, tell the doctor or pharmacist that you are also taking a beta-2 reliever, and ask which diuretics are safe. If you have high blood pressure, a heart problem, or a thyroid condition, make sure the doctor remembers this when prescribing beta-2 relievers.
Adrenaline inhalers
Adrenaline inhalers are for use in emergencies. Technically, they are not available in Britain, but they can be imported under special licence, and your doctor may be persuaded to obtain one for you if he or she thinks it might be useful. They are given to people who have asthma and have sometimes had attacks of anaphylaxis (see p. 58), for example in reaction to food, latex or an insect sting. The inhaler provides prompt emergency treatment for the kind of severe asthma attack that you may experience during anaphylaxis.
You should probably be carrying an adrenaline auto-injector as well, as you may need to use both (see p. 98). Those who usually have fairly mild reactions to their allergen can use the inhaler first, to treat symptoms in the mouth, throat and airways. If other symptoms develop, such as faintness or widespread nettle rash,
Asthma alert
If you ever find that your short-acting beta-2 reliever has no effect within ten minutes, or is needed more than once every four hours, this indicates a serious asthma attack and you need urgent medical help (see p. 100).
During a severe asthma attack, while getting to hospital or waiting for a doctor to arrive, up to 30 puffs of a short-acting beta-2 reliever should be taken as an emergency treatment, to get the airways open. There is a risk of death if you don’t use the reliever fully in this situation. (This emergency dose is safe for almost everyone, but there may be risks if you have a heart condition – get detailed advice from your doctor in advance.)
then the adrenaline injector can be used. Those with a history of more severe reactions should start with the adrenaline injector and then use the inhaler if there are still symptoms in the mouth or airways.
Don’t exceed the maximum number of puffs stated on the canister, as the propellant can cause problems. If you have a heart condition, your doctor will advise you about using this kind of treatment safely - adrenaline can affect the heart.
Ephedrine
Ephedrine and orciprenaline (brand name Alupent) belong to the previous generation of reliever drugs. They are chemically very similar to adrenaline and therefore cause a lot of side effects, especially involving the heart.
These drugs are no longer recommended, and will soon be phased out completely. Some older asthmatics may still be using them, just because they have been on them for years and no one has reviewed their treatment.
If you are taking such drugs, ask your doctor about switching to a newer form of reliever - it will be more effective in treating your asthma, as well as having fewer side effects.
Anti -cho linerg ics
These drugs, also known as anti-muscarinics, are relievers. However, they work in a completely different way from the beta-2 relievers. They block the action of the parasympathetic nervous system, a set of nerves that are the biological equivalent of auto-pilot - working without the intervention of conscious thought. The parasympathetic nervous system has many effects on the body, including keeping the airway muscles nicely toned (see box on p. 235). By blocking the parasympathetic, anticholinergics help the airway muscles to relax.
Anti-cholinergics are taken by inhaler, and require 30-90 minutes to achieve their full effects. They should continue working for 3-6 hours.
Some common brand names
Common brand names of anti-cholinergics include: inhalers – Atrovent, Oxivent
nasal spray - Rinatec
For most asthmatics, especially those with a strong allergic component to their asthma, anti-cholinergics are generally less effective than beta-2 relievers. But they are useful to children under one year, who may not respond to beta-2 relievers. They also have a role where asthma is combined with chronic bronchitis -here the anti -choli nerg ics can sometimes be more effective than beta-2 relievers - and they are particularly useful for asthma with a lot of mucus, because blocking the parasympathetic tends to reduce mucus production. For severe asthmatics, anticholinergics may be combined with beta-2 relievers.
Anti -choli nerg ics should be taken only when needed, not regularly several times a day. If used regularly, they can make the airways more sensitive, just as short-acting beta-2 relievers can (see p. 153).
Side effects
Minor side effects of anti-cholinergics may include a dry mouth, blurred vision, constipation, and irritation of the mouth and throat. A few people suffer nausea or difficulty in passing urine.
Serious side effects are rare. Any increase in the stickiness of the sputum coughed up may be a cause for concern, especially in children. If there is an increase in wheezing or coughing, stop taking the drug and see your doctor.
If you already have glaucoma or prostate problems you should be monitored carefully by your doctor, as these conditions can get worse with anti -choli nerg ic drugs.
When anti -choli nerg ics are used in a nebuliser, it is vital that the mask fits well (see p. 163).
Anti-cholinergics for the nose
Another use for anti-cholinergics is in nasal sprays, for the treatment of vasomotor rhinitis, a non-allergic condition that is frequently mistaken for allergic rhinitis (see p. 29). In this disorder, the constant flow of mucus is caused by a malfunction of the parasympathetic nervous system, which is why anti-cholinergics work well.
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